Anhydron
Anhydron Brand names, Anhydron Analogs
Anhydron Brand Names Mixture
- Zylet (0.5% loteprednol etabonate + 0.3% tobramycin)
Anhydron Chemical_Formula
C14H16ClN3O4S2
Anhydron RX_link
No information avaliable
Anhydron fda sheet
Anhydron msds (material safety sheet)
Anhydron Synthesis Reference
No information avaliable
Anhydron Molecular Weight
389.879 g/mol
Anhydron Melting Point
227-228oC
Anhydron H2O Solubility
No information avaliable
Anhydron State
Solid
Anhydron LogP
1.048
Anhydron Dosage Forms
Tablets (oral, 5mg)
Anhydron Indication
Cyclothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension.
Anhydron Pharmacology
Like other thiazides, cyclothiazide promotes water loss from the body (diuretics). It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. Cyclothiazide affects the distal renal tubular mechanism of electrolyte reabsorption. At maximal therapeutic dosages, all thiazides are approximately equal in their diuretic efficacy. Cyclothiazide increases excretion of sodium and chloride in approximately equivalent amounts. Natriuresis may be accompanied by some loss of potassium and bicarbonate.
Anhydron Absorption
No information avaliable
Anhydron side effects and Toxicity
Oral LD50 in mouse is > 10000 mg/kg, and > 4000 mg/kg in rat. Signs of overdose include those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis has also been administered hypokalemia may accentuate cardiac arrhythmias.
Anhydron Patient Information
Anhydron Organisms Affected
Humans and other mammals
