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Brand names,
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Analogs
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Brand Names Mixture
- Aldactazide 25 (Hydrochlorothiazide + Spironolactone)
- Aldactazide 50 (Hydrochlorothiazide + Spironolactone)
- Apo-Spirozide Tab (Hydrochlorothiazide + Spironolactone)
- Novo-Spirozine Tab 25mg (Hydrochlorothiazide + Spironolactone)
- Novo-Spirozine-50 Tab (Hydrochlorothiazide + Spironolactone)
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Chemical_Formula
C20H29FO3
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RX_link
http://www.rxlist.com/cgi/generic2/fluoxy.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
336.441 g/mol
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Melting Point
270 oC
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H2O Solubility
67.5 mg/L
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State
Solid
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LogP
2.537
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Dosage Forms
Tablet
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Indication
In males, used as replacement therapy in conditions associated with symptoms of deficiency or absence of endogenous testosterone. In females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal.
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Pharmacology
Fluoxymesterone is a synthetic androgen, or male hormone, similar to testosterone. Fluoxymesterone works by attaching itself to androgen receptors; this causes it to interact with the parts of the cell involved in the making of proteins. It may cause an increase in the synthesis of some proteins or a decrease in the synthesis of others. These proteins have a variety of effects, including blocking the growth of some types of breast cancer cells, stimulating cells that cause male sexual characteristics, and stimulating the production of red blood cells.
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Absorption
Oral absorption is less than 44%.
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side effects and Toxicity
Side effects include virilization (masculine traits in women), acne, fluid retention, and hypercalcemia.
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Patient Information
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Organisms Affected
Humans and other mammals