Anagrelide
Anagrelide Brand names, Anagrelide Analogs
Anagrelide Brand Names Mixture
- No information avaliable
Anagrelide Chemical_Formula
C10H7Cl2N3O
Anagrelide RX_link
http://www.rxlist.com/cgi/generic/anagrel.htm
Anagrelide fda sheet
Anagrelide msds (material safety sheet)
Anagrelide Synthesis Reference
No information avaliable
Anagrelide Molecular Weight
256.088 g/mol
Anagrelide Melting Point
280 oC
Anagrelide H2O Solubility
Very slightly soluble
Anagrelide State
Solid
Anagrelide LogP
2.333
Anagrelide Dosage Forms
Capsules (0.5 mg or 1 mg)
Anagrelide Indication
For the treatment of patients with thrombocythemia, secondary to myeloproliferative disorders, to reduce the elevated platelet count and the risk of thrombosis and to ameliorate associated symptoms including thrombo-hemorrhagic events.
Anagrelide Pharmacology
Anagrelide is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia). It works by inhibiting the maturation of megakaryocytes into platelets. The exact mechanism of action is unclear, although it is known to be a potent (IC50 = 36nM) inhibitor of phosphodiesterase-III.
Anagrelide Absorption
No information avaliable
Anagrelide side effects and Toxicity
There are no reports of overdosage with anagrelide, however thrombocytopenia, which can potentially cause bleeding, is expected from overdosage. Single oral doses of anagrelide at 2,500, 1,500 and 200 mg/kg in mice, rats and monkeys, respectively, were not lethal. Symptoms of acute toxicity were: decreased motor activity in mice and rats and softened stools and decreased appetite in monkeys.
Anagrelide Patient Information
Anagrelide Organisms Affected
Humans and other mammals
