Anagrelide HCL
Anagrelide HCL Brand names, Anagrelide HCL Analogs
Anagrelide HCL Brand Names Mixture
- No information avaliable
Anagrelide HCL Chemical_Formula
C10H7Cl2N3O
Anagrelide HCL RX_link
http://www.rxlist.com/cgi/generic/anagrel.htm
Anagrelide HCL fda sheet
Anagrelide HCL msds (material safety sheet)
Anagrelide HCL Synthesis Reference
No information avaliable
Anagrelide HCL Molecular Weight
256.088 g/mol
Anagrelide HCL Melting Point
280 oC
Anagrelide HCL H2O Solubility
Very slightly soluble
Anagrelide HCL State
Solid
Anagrelide HCL LogP
2.333
Anagrelide HCL Dosage Forms
Capsules (0.5 mg or 1 mg)
Anagrelide HCL Indication
For the treatment of patients with thrombocythemia, secondary to myeloproliferative disorders, to reduce the elevated platelet count and the risk of thrombosis and to ameliorate associated symptoms including thrombo-hemorrhagic events.
Anagrelide HCL Pharmacology
Anagrelide is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia). It works by inhibiting the maturation of megakaryocytes into platelets. The exact mechanism of action is unclear, although it is known to be a potent (IC50 = 36nM) inhibitor of phosphodiesterase-III.
Anagrelide HCL Absorption
No information avaliable
Anagrelide HCL side effects and Toxicity
There are no reports of overdosage with anagrelide, however thrombocytopenia, which can potentially cause bleeding, is expected from overdosage. Single oral doses of anagrelide at 2,500, 1,500 and 200 mg/kg in mice, rats and monkeys, respectively, were not lethal. Symptoms of acute toxicity were: decreased motor activity in mice and rats and softened stools and decreased appetite in monkeys.
Anagrelide HCL Patient Information
Anagrelide HCL Organisms Affected
Humans and other mammals
