Amdinocillin
Amdinocillin Brand names, Amdinocillin Analogs
Amdinocillin Brand Names Mixture
- No information avaliable
Amdinocillin Chemical_Formula
C21H33N3O5S
Amdinocillin RX_link
No information avaliable
Amdinocillin fda sheet
Amdinocillin msds (material safety sheet)
Amdinocillin Synthesis Reference
No information avaliable
Amdinocillin Molecular Weight
439.57 g/mol
Amdinocillin Melting Point
156 oC
Amdinocillin H2O Solubility
Insoluble
Amdinocillin State
Solid
Amdinocillin LogP
3.09
Amdinocillin Dosage Forms
Injection
Amdinocillin Indication
Used in the treatment of urinary tract infections caused by some strains of E. coli and klebsiella and enterobacter species.
Amdinocillin Pharmacology
Amdinocillin is a novel, semisynthetic penicillin effective against many gram-negative bacteria. The antibacterial activity of amdinocillin is derived from its ability to bind specifically and avidly to Penicillin Binding Protein-2 (PBP 2). Amdinocillin is active alone against many gram-negative organisms. Pseudomonas and non-fermenting gram-negative bacteria, however, are usually resistant. Amdinocillin, in combination with many beta-lactams, exhibits marked synergy against many enterobacteriaceae. No such synergy can be demonstrated for gram-positive organisms or pseudomonas species. Amdinocillin is not beta-lactamase stable. Organisms which produce high levels of plasma-mediated beta-lactamase are resistant to the drug. Co-administration of probenecid results in markedly elevated plasma levels of amdinocillin and delays its excretion.
Amdinocillin Absorption
Poorly absorbed if given orally.
Amdinocillin side effects and Toxicity
No information avaliable
Amdinocillin Patient Information
Amdinocillin Organisms Affected
Gram-negative Bacteria
