Coactin

• Anti-bacterial Agents
• Penicillins
• ATC:J01CA0

• Coactin

• No information avaliable

C₂₁H₃₃N₃O₅S

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Coactin MSDS

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439.57 g/mol

156 ^oC

Insoluble

Solid

3.09

Injection

Used in the treatment of urinary tract infections caused by some strains of E. coli and klebsiella and enterobacter species.

Amdinocillin is a novel, semisynthetic penicillin effective against many gram-negative bacteria. The antibacterial activity of amdinocillin is derived from its ability to bind specifically and avidly to Penicillin Binding Protein-2 (PBP 2). Amdinocillin is active alone against many gram-negative organisms. Pseudomonas and non-fermenting gram-negative bacteria, however, are usually resistant. Amdinocillin, in combination with many beta-lactams, exhibits marked synergy against many enterobacteriaceae. No such synergy can be demonstrated for gram-positive organisms or pseudomonas species. Amdinocillin is not beta-lactamase stable. Organisms which produce high levels of plasma-mediated beta-lactamase are resistant to the drug. Co-administration of probenecid results in markedly elevated plasma levels of amdinocillin and delays its excretion.

Poorly absorbed if given orally.

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Gram-negative Bacteria