Coactin
Coactin Brand names, Coactin Analogs
Coactin Brand Names Mixture
- No information avaliable
Coactin Chemical_Formula
C21H33N3O5S
Coactin RX_link
No information avaliable
Coactin fda sheet
Coactin msds (material safety sheet)
Coactin Synthesis Reference
No information avaliable
Coactin Molecular Weight
439.57 g/mol
Coactin Melting Point
156 oC
Coactin H2O Solubility
Insoluble
Coactin State
Solid
Coactin LogP
3.09
Coactin Dosage Forms
Injection
Coactin Indication
Used in the treatment of urinary tract infections caused by some strains of E. coli and klebsiella and enterobacter species.
Coactin Pharmacology
Amdinocillin is a novel, semisynthetic penicillin effective against many gram-negative bacteria. The antibacterial activity of amdinocillin is derived from its ability to bind specifically and avidly to Penicillin Binding Protein-2 (PBP 2). Amdinocillin is active alone against many gram-negative organisms. Pseudomonas and non-fermenting gram-negative bacteria, however, are usually resistant. Amdinocillin, in combination with many beta-lactams, exhibits marked synergy against many enterobacteriaceae. No such synergy can be demonstrated for gram-positive organisms or pseudomonas species. Amdinocillin is not beta-lactamase stable. Organisms which produce high levels of plasma-mediated beta-lactamase are resistant to the drug. Co-administration of probenecid results in markedly elevated plasma levels of amdinocillin and delays its excretion.
Coactin Absorption
Poorly absorbed if given orally.
Coactin side effects and Toxicity
No information avaliable
Coactin Patient Information
Coactin Organisms Affected
Gram-negative Bacteria
