Adenosine aminohydrolase
Brand names,
Adenosine aminohydrolase
Analogs
Adenosine aminohydrolase
Brand Names Mixture
Adenosine aminohydrolase
Chemical_Formula
C1821H2834N484O552S14
Adenosine aminohydrolase
RX_link
http://www.rxlist.com/cgi/generic2/pegademase.htm
Adenosine aminohydrolase
fda sheet
Adenosine aminohydrolase
msds (material safety sheet)
Adenosine aminohydrolase
Synthesis Reference
No information avaliable
Adenosine aminohydrolase
Molecular Weight
40788.2
Adenosine aminohydrolase
Melting Point
MacQuarrie R, Buel E. Physical and catalytic properties of the isozymes of adenosine deaminase from human red blood cells.
Adenosine aminohydrolase
H2O Solubility
No information avaliable
Adenosine aminohydrolase
State
Liquid
Adenosine aminohydrolase
LogP
-0.428
Adenosine aminohydrolase
Dosage Forms
Solution (IM Injection)
Adenosine aminohydrolase
Indication
For treatment of adenosine deaminase deficiency
Adenosine aminohydrolase
Pharmacology
Used to replace deficient or inactive adenosine deaminase which leads to severe combined immunodeficiency disease (SCID). The enzyme is responsible for converting adensoine to inosine. In the absence of adenosine deaminase, the purine substrates adenosine, 2'-deoxyadenosine and their metabolites are actually toxic to lymphocytes thereby leading to diminished immune function.
Adenosine aminohydrolase
Absorption
No information avaliable
Adenosine aminohydrolase
side effects and Toxicity
No information avaliable
Adenosine aminohydrolase
Patient Information
No information avaliable
Adenosine aminohydrolase
Organisms Affected
Humans and other mammals