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Prenolol
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Prenolol Brand names, Prenolol Analogs

Prenolol Brand Names Mixture

  • Tenoretic (atenolol + chlorthalidone)

Prenolol Chemical_Formula

C14H22N2O3

Prenolol RX_link

http://www.rxlist.com/cgi/generic/atenolol.htm

Prenolol fda sheet

Prenolol msds (material safety sheet)

Prenolol Synthesis Reference

Barrett et al., U.S. Pat. 3,,663,607 (1972)

Prenolol Molecular Weight

266.336 g/mol

Prenolol Melting Point

146-148oC

Prenolol H2O Solubility

13.5 mg/mL

Prenolol State

Solid

Prenolol LogP

1.256

Prenolol Dosage Forms

Tablet (25, 50 and 100 mg); Intravenous injection

Prenolol Indication

For the management of hypertention and long-term management of patients with angina pectoris

Prenolol Pharmacology

Atenolol, a competitive beta(1)-selective adrenergic antagonist, has the lowest lipid solubility of this drug class. Although it is similar to metoprolol, atenolol differs from pindolol and propranolol in that it does not have intrinsic sympathomimetic properties or membrane-stabilizing activity. Atenolol is used alone or with chlorthalidone in the management of hypertension and edema.

Prenolol Absorption

oral dose if rapid and consisten but incomplete. Approximately 50% of an oral dose is absorbed from the gastrointestinal tract, the remainder being excreted unchanged in the feces.

Prenolol side effects and Toxicity

LD50=2000-3000 mg/kg(orally in mice). Symptoms of an atenolol overdose include a slow heart beat, shortness of breath, fainting, dizziness, weakness, confusion, nausea, and vomiting.

Prenolol Patient Information

This belongs to the group of medicines known as beta-blockers. Atenolol can
be used to treat high blood pressure, angina (chest pain) and irregular
heartbeat. It has varied effects in different parts of the body. High Blood
Pressure: Atenolol works by blocking the transmission of messages to the beta
receptors in the heart which slows down the activity of the heart, decreasing
blood pressure. Angina: Atenolol works by blocking the transmission of messages
to the beta receptors in the heart which slows down the activity of the heart
and reduces the heart's need for oxygen. This makes angina attacks less likely
to occur. Irregular Heartbeat: Normally the heartbeat is regulated by special
tissues which conduct electricity. Some cases of irregular heartbeat are caused
by these tissues conducting electricity too quickly. Atenolol works by reducing
over-activity in the conducting tissue.

Prenolol Organisms Affected

Humans and other mammals