Prenolol
Category
Prenolol Brand names, Prenolol Analogs
Prenolol Brand Names Mixture
- Tenoretic (atenolol + chlorthalidone)
Prenolol Chemical_Formula
C14H22N2O3
Prenolol RX_link
http://www.rxlist.com/cgi/generic/atenolol.htm
Prenolol fda sheet
Prenolol msds (material safety sheet)
Prenolol Synthesis Reference
Barrett et al., U.S. Pat. 3,,663,607 (1972)
Prenolol Molecular Weight
266.336 g/mol
Prenolol Melting Point
146-148oC
Prenolol H2O Solubility
13.5 mg/mL
Prenolol State
Solid
Prenolol LogP
1.256
Prenolol Dosage Forms
Tablet (25, 50 and 100 mg); Intravenous injection
Prenolol Indication
For the management of hypertention and long-term management of patients with angina pectoris
Prenolol Pharmacology
Atenolol, a competitive beta(1)-selective adrenergic antagonist, has the lowest lipid solubility of this drug class. Although it is similar to metoprolol, atenolol differs from pindolol and propranolol in that it does not have intrinsic sympathomimetic properties or membrane-stabilizing activity. Atenolol is used alone or with chlorthalidone in the management of hypertension and edema.
Prenolol Absorption
oral dose if rapid and consisten but incomplete. Approximately 50% of an oral dose is absorbed from the gastrointestinal tract, the remainder being excreted unchanged in the feces.
Prenolol side effects and Toxicity
LD50=2000-3000 mg/kg(orally in mice). Symptoms of an atenolol overdose include a slow heart beat, shortness of breath, fainting, dizziness, weakness, confusion, nausea, and vomiting.
Prenolol Patient Information
This belongs to the group of medicines known as beta-blockers. Atenolol can
be used to treat high blood pressure, angina (chest pain) and irregular
heartbeat. It has varied effects in different parts of the body. High Blood
Pressure: Atenolol works by blocking the transmission of messages to the beta
receptors in the heart which slows down the activity of the heart, decreasing
blood pressure. Angina: Atenolol works by blocking the transmission of messages
to the beta receptors in the heart which slows down the activity of the heart
and reduces the heart's need for oxygen. This makes angina attacks less likely
to occur. Irregular Heartbeat: Normally the heartbeat is regulated by special
tissues which conduct electricity. Some cases of irregular heartbeat are caused
by these tissues conducting electricity too quickly. Atenolol works by reducing
over-activity in the conducting tissue.
Prenolol Organisms Affected
Humans and other mammals
