Nitrendipino [Inn-Spanish]

• Vasodilator Agents
• Antihypertensive Agents
• ATC:C08CA08
• Calcium Channel Blockers

• Bayotensin
• Baypress
• Bylotensin
• Deiten
• Nidrel
• Nitrendipin
• Nitrendipine [Usan:Ban:Inn:Jan]
• Nitrendipine, Pharma
• Nitrendipino [Inn-Spanish]
• Nitrendipinum [Inn-Latin]
• Nitrepin

• No information avaliable

C₁₈H₂₀N₂O₆

No information avaliable

H. Meyar et al., Ger. pat 2117571; eidem, US pat. 3799934

360.361 g/mol

156-160 ^oC

Insoluble

Solid

2.756

No information avaliable

For the treatment of mild to moderate hypertension

Nitrendipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nitrendipine is similar to other peripheral vasodilators. Nitrendipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

No information avaliable

No information avaliable

No information avaliable

Humans and other mammals