McN-JR 4749

• Antidotes
• Cholinesterase Inhibitors

• DHBP
• Dehidrobenzperidol
• Dehydrobenzperidol
• Deidrobenzperidolo
• Dihidrobenzperidol
• Dridol
• Droleptan
• Halkan
• Inappin
• Inapsin
• Inapsine
• Innovan
• Innovar
• Innovar-Vet
• Inopsin
• Inoval
• Leptanal
• Leptofen
• McN-JR 4749
• Properidol
• Sintodril
• Sintosian
• Thalamanol
• Thalamonal
• Vetkalm

• No information avaliable

C₁₀H₁₆NO+

http://www.rxlist.com/cgi/generic3/edrophonium.htm

McN-JR_4749 MSDS

No information avaliable

166.24 g/mol

No information avaliable

Appreciable as liquid hydrochloride salt

Liquid

-2.95

Liquid for injection

For the differential diagnosis of myasthenia gravis and as an adjunct in the evaluation of treatment requirements in this disease. It may also be used for evaluating emergency treatment in myasthenic crises.

Edrophonium is a short and rapid-acting anticholinesterase drug. Its effect is manifest within 30 to 60 seconds after injection and lasts an average of 10 minutes. Edrophonium's pharmacologic action is due primarily to the inhibition or inactivation of acetylcholinesterase at sites of cholinergic transmission. Muscarinic receptors are found throughout the body, especially on muscle. Stimulation of these receptors causes to muscle contraction. In myasthenia gravis the body's immune system destroys many of the muscarinic receptors, so that the muscle becomes less responsive to nervous stimulation. Edrophonium chloride increases the amount of acetylcholine at the nerve endings. Increased levels of acetyl choline allow the remaining receptors to function more efficiently.

Rapidly absorbed.

With drugs of this type, muscarine-like symptoms (nausea, vomiting, diarrhea, sweating, increased bronchial and salivary secretions and bradycardia) often appear with overdosage (cholinergic crisis).

No information avaliable

Humans and other mammals