Ketoconazole
Ketoconazole Brand names, Ketoconazole Analogs
Ketoconazole Brand Names Mixture
- No information avaliable
Ketoconazole Chemical_Formula
C26H28Cl2N4O4
Ketoconazole RX_link
http://www.rxlist.com/cgi/generic/ketocon.htm
Ketoconazole fda sheet
Ketoconazole msds (material safety sheet)
Ketoconazole Synthesis Reference
J. Heeres et al., U.S. Pat. 4,144,346 (1979)
Ketoconazole Molecular Weight
531.43 g/mol
Ketoconazole Melting Point
146 oC
Ketoconazole H2O Solubility
0.0866 mg/L
Ketoconazole State
Solid
Ketoconazole LogP
3.651
Ketoconazole Dosage Forms
Tablets; Shampoo; Cream; Suspension
Ketoconazole Indication
For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
Ketoconazole Pharmacology
Ketoconazole, like clotrimazole, fluconazole, itraconazole, and miconazole, is an imidazole antifungal agent.
Ketoconazole Absorption
Moderate
Ketoconazole side effects and Toxicity
Hepatotoxicity, LD50=86 mg/kg (orally in rat)
Ketoconazole Patient Information
Shampoo: May be irritating to mucous membranes of the eyes and contact with this area should be avoided.
There have been reports that use of the shampoo resulted in removal of the curl from permanently waved hair.
Tablet: Patients should be instructed to report any signs and symptoms which may suggest liver dysfunction so that appropriate biochemical testing can be done. Such signs and symptoms may include unusual fatigue, anorexia, nausea and/or vomiting, jaundice, dark urine or pale stools
Ketoconazole Organisms Affected
Fungi
