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Glynase Brand names, Glynase Analogs

Glynase Brand Names Mixture

  • No information avaliable

Glynase Chemical_Formula

C23H28ClN3O5S

Glynase RX_link

http://www.rxlist.com/cgi/generic/glybur.htm

Glynase fda sheet

Glynase msds (material safety sheet)

Glynase MSDS

Glynase Synthesis Reference

Weber et al., U.S. Pat. 3,454,635 (1969)

Glynase Molecular Weight

494.004 g/mol

Glynase Melting Point

169-170oC

Glynase H2O Solubility

4 mg/L

Glynase State

Solid

Glynase LogP

4.85

Glynase Dosage Forms

Tablet (1.25 mg, 2.5 mg, 5 mg)

Glynase Indication

Indicated as an adjunct to diet to lower the blood glucose in patients with non-insulin-dependent diabetes mellitus (Type II) whose hyperglycemia cannot be satisfactorily controlled by diet alone.

Glynase Pharmacology

Glyburide, a second-generation sulfonylurea antidiabetic agent, appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. With chronic administration in Type II diabetic patients, the blood glucose lowering effect persists despite a gradual decline in the insulin secretory response to the drug. Extrapancreatic effects may be involved in the mechanism of action of oral sulfonyl-urea hypoglycemic drugs. The combination of glyburide and metformin may have a synergistic effect, since both agents act to improve glucose tolerance by different but complementary mechanisms. In addition to its blood glucose lowering actions, glyburide produces a mild diuresis by enhancement of renal free water clearance. Glyburide is twice as potent as the related second-generation agent glipizide.

Glynase Absorption

Significant absorption within 1 hour and peak plasma levels are reached within 4 hours.

Glynase side effects and Toxicity

Oral rat LD50: > 20,000 mg/kg. Oral mouse LD50: 3250 mg/kg.

Glynase Patient Information

Patients should be informed of the potential risks and advantages of MICRONASE and of alternative modes of therapy. They also should be informed about the importance of adherence to dietary instructions, of a regular exercise program, and of regular testing of urine and/or blood glucose.

The risks of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development should be explained to patients and responsible family members. Primary and secondary failure also should be explained.

Glynase Organisms Affected

Humans and other mammals