Arabinosyladenine_Triphosphate
Category
Arabinosyladenine_Triphosphate Brand names, Arabinosyladenine_Triphosphate Analogs
Arabinosyladenine_Triphosphate Brand Names Mixture
No information avaliable
Arabinosyladenine_Triphosphate Chemical_Formula
C10H15N5O5
Arabinosyladenine_Triphosphate RX_link
http://www.rxlist.com/cgi/generic3/vidarabine.htm
Arabinosyladenine_Triphosphate fda sheet
Arabinosyladenine_Triphosphate msds (material safety sheet)
Arabinosyladenine_Triphosphate Synthesis Reference
No information avaliable
Arabinosyladenine_Triphosphate Molecular Weight
285.257 g/mol
Arabinosyladenine_Triphosphate Melting Point
No information avaliable
Arabinosyladenine_Triphosphate H2O Solubility
No information avaliable
Arabinosyladenine_Triphosphate State
Solid
Arabinosyladenine_Triphosphate LogP
-2.115
Arabinosyladenine_Triphosphate Dosage Forms
No information avaliable
Arabinosyladenine_Triphosphate Indication
For treatment of chickenpox - varicella, herpes zoster and herpes simplex
Arabinosyladenine_Triphosphate Pharmacology
Vidarabine is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). The inhibitory activity of Vidarabine is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts Vidarabine into Vidarabine monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. in vitro, Vidarabine triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, Vidarabine triphosphate competitively inhibits dATP leading to the formation of 'faulty' DNA. This is where Vidarabine triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand.
Arabinosyladenine_Triphosphate Absorption
No information avaliable
Arabinosyladenine_Triphosphate Toxicity
No information avaliable
Arabinosyladenine_Triphosphate Patient Information
No information avaliable
Arabinosyladenine_Triphosphate Organisms Affected
Human Herpes Viruses
