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Arabinofuranosyladenine_Triphosphate
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Arabinofuranosyladenine Triphosphate Brand names, Arabinofuranosyladenine Triphosphate Analogs

Arabinofuranosyladenine Triphosphate Brand Names Mixture

  • No information avaliable

Arabinofuranosyladenine Triphosphate Chemical_Formula

C10H15N5O5

Arabinofuranosyladenine Triphosphate RX_link

http://www.rxlist.com/cgi/generic3/vidarabine.htm

Arabinofuranosyladenine Triphosphate fda sheet

Arabinofuranosyladenine Triphosphate msds (material safety sheet)

Arabinofuranosyladenine Triphosphate Synthesis Reference

No information avaliable

Arabinofuranosyladenine Triphosphate Molecular Weight

285.257 g/mol

Arabinofuranosyladenine Triphosphate Melting Point

No information avaliable

Arabinofuranosyladenine Triphosphate H2O Solubility

No information avaliable

Arabinofuranosyladenine Triphosphate State

Solid

Arabinofuranosyladenine Triphosphate LogP

-2.115

Arabinofuranosyladenine Triphosphate Dosage Forms

No information avaliable

Arabinofuranosyladenine Triphosphate Indication

For treatment of chickenpox - varicella, herpes zoster and herpes simplex

Arabinofuranosyladenine Triphosphate Pharmacology

Vidarabine is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). The inhibitory activity of Vidarabine is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts Vidarabine into Vidarabine monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. in vitro, Vidarabine triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, Vidarabine triphosphate competitively inhibits dATP leading to the formation of 'faulty' DNA. This is where Vidarabine triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand.

Arabinofuranosyladenine Triphosphate Absorption

No information avaliable

Arabinofuranosyladenine Triphosphate side effects and Toxicity

No information avaliable

Arabinofuranosyladenine Triphosphate Patient Information

No information avaliable

Arabinofuranosyladenine Triphosphate Organisms Affected

Human Herpes Viruses