Adenine_Arabinoside
Category
Adenine_Arabinoside Brand names, Adenine_Arabinoside Analogs
Adenine_Arabinoside Brand Names Mixture
No information avaliable
Adenine_Arabinoside Chemical_Formula
C10H15N5O5
Adenine_Arabinoside RX_link
http://www.rxlist.com/cgi/generic3/vidarabine.htm
Adenine_Arabinoside fda sheet
Adenine_Arabinoside msds (material safety sheet)
Adenine_Arabinoside Synthesis Reference
No information avaliable
Adenine_Arabinoside Molecular Weight
285.257 g/mol
Adenine_Arabinoside Melting Point
No information avaliable
Adenine_Arabinoside H2O Solubility
No information avaliable
Adenine_Arabinoside State
Solid
Adenine_Arabinoside LogP
-2.115
Adenine_Arabinoside Dosage Forms
No information avaliable
Adenine_Arabinoside Indication
For treatment of chickenpox - varicella, herpes zoster and herpes simplex
Adenine_Arabinoside Pharmacology
Vidarabine is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). The inhibitory activity of Vidarabine is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts Vidarabine into Vidarabine monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. in vitro, Vidarabine triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, Vidarabine triphosphate competitively inhibits dATP leading to the formation of 'faulty' DNA. This is where Vidarabine triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand.
Adenine_Arabinoside Absorption
No information avaliable
Adenine_Arabinoside Toxicity
No information avaliable
Adenine_Arabinoside Patient Information
No information avaliable
Adenine_Arabinoside Organisms Affected
Human Herpes Viruses
