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  • Obide Formule chimique

    C18H20FN3O4

    Obide RX lien

    http://www.rxlist.com/cgi/generic/oflox.htm

    Obide FDA fiche

    Obide FDA

    Obide msds (fiche de securite des materiaux)

    Obide MSDS

    Obide Synthese de reference

    I. Hayakava et al., US. 4,382,892 (1983)

    Obide Poids moleculaire

    361.368 g/mol

    Obide Point de fusion

    250-257 oC

    Obide H2O Solubilite

    28,3 mg / ml

    Obide Etat

    Solid

    Obide LogP

    1.268

    Obide Formes pharmaceutiques

    Solution (injection IV); Tablet; gouttes ophtalmiques

    Obide Indication

    Pour le traitement des infections (voies respiratoires, les reins, la peau, des tissus mous, infections urinaires), l'urètre et le col de l'utérus gonorrhée.

    Obide Pharmacologie

    Ofloxacine est un antibiotique de la famille des quinolones / fluoroquinolones. Ofloxacine est bactéricide et son mode d'action repose sur le blocage de la réplication de l'ADN bactérien en se liant à une enzyme appelée ADN gyrase, qui permet la détorsion nécessaire pour répliquer une double hélice d'ADN en deux. Notamment le médicament a une affinité 100 fois plus élevée pour l'ADN gyrase bactérienne que pour les mammifères. Ofloxacine est un large spectre antibiotique actif contre les bactéries tant Gram-positives et gram-négatives.

    Obide Absorption

    La biodisponibilité de l'ofloxacine dans la formulation comprimé est d'environ 98%

    Obide Toxicite

    DL50 = 5450 mg / kg (par voie orale chez la souris)

    Obide Information pour les patients

    PATIENT INFORMATION
    Patients should be advised:

    - to drink fluids liberally;

    - that mineral supplements, vitamins with iron or minerals, calcium- , aluminum-, or magnesium-based
    antacids, sucralfate or Videx, (Didanosine), chewable/buffered tablets or the pediatric powder for
    oral solution should not be taken within the two-hour period before or within the two-hour period after
    taking ofloxacin (See Drug Interactions);

    - that ofloxacin can be taken without regard to meals;

    - that ofloxacin may cause neurologic adverse effects (e. g. , dizziness, lightheadedness) and that
    patients should know how they react to ofloxacin before they operate an automobile or machinery or
    engage in activities requiring mental alertness and coordination

    - to discontinue treatment and inform their physician if they experience pain, inflammation, or rupture
    of a tendon, and to rest and refrain from exercise until the diagnosis of tendinitis or tendon rupture
    has been confidently excluded;



    - that ofloxacin may be associated with hypersensitivity reactions, even following the first dose, to
    discontinue the drug at the first sign of a skin rash, hives or other skin reactions, a rapid heartbeat,
    difficulty in swallowing or breathing, any swelling suggesting angioedema (e. g. , swelling of the lips,
    tongue, face; tightness of the throat, hoarseness), or any other symptom of an allergic reaction

    - to avoid excessive sunlight or artificial ultraviolet light while receiving ofloxacin and to discontinue
    therapy if phototoxicity (e. g. , skin eruption) occurs;

    - that if they are diabetic and are being treated with insulin or an oral hypoglycemic drug, to discontinue
    ofloxacin immediately if a hypoglycemic reaction occurs and consult a physician

    - that convulsions have been reported in patients taking quinolones, including ofloxacin, and to notify their
    physician before taking this drug if there is a history of this condition.

    Obide Organismes affectes

    Bactéries entériques et d'autres eubactéries