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Mometasone furoate Les marques, Mometasone furoate Analogs

Mometasone furoate Les marques melange

  • Combisor (Mometasone + Salicyclic Acid)
  • Mometasone furoate Formule chimique

    C22H28Cl2O4

    Mometasone furoate RX lien

    http://www.rxlist.com/cgi/generic2/momet1.htm

    Mometasone furoate FDA fiche

    Mometasone_furoate FDA

    Mometasone furoate msds (fiche de securite des materiaux)

    Mometasone furoate Synthese de reference

    EL Shapiro, le brevet américain. 4,472,393 (1984)

    Mometasone furoate Poids moleculaire

    427.361 g/mol

    Mometasone furoate Point de fusion

    218-220oC

    Mometasone furoate H2O Solubilite

    Pratiquement insoluble.

    Mometasone furoate Etat

    Solid

    Mometasone furoate LogP

    3.052

    Mometasone furoate Formes pharmaceutiques

    Vaporisateur nasal; Poudre pour inhalation; Crème

    Mometasone furoate Indication

    L'inhalateur est indiqué pour le traitement d'entretien de l'asthme comme traitement prophylactique. Le spray nasal est indiqué pour le traitement des symptômes nasaux de la rhinite allergique saisonnière et perannuelle allergique.

    Mometasone furoate Pharmacologie

    Mométasone est un synthétique de moyenne puissance avec des corticoïdes anti-inflammatoires, antiprurigineux, et des propriétés vasoconstrictrices. Des études chez des patients asthmatiques ont démontré que mométasone fournit une rapport favorable de l'actualité à l'activité systémique en raison de son effet primaire locale avec le métabolisme hépatique et l'absence de métabolites actifs. Bien qu'elles soient efficaces pour le traitement de l'asthme, glucocorticoïdes ne touchent pas les symptômes d'asthme immédiatement. Amélioration maximale des symptômes après l'administration par inhalation de furoate de mométasone peut pas être atteint de 1 à 2 semaines ou plus après le démarrage traitement. Lorsque les glucocorticoïdes sont abandonnées, la stabilité d'asthme peuvent persister pendant plusieurs jours ou plus. Mométasone a été montré in vitro pour présenter une affinité de liaison pour le glucocorticoïde humain récepteur qui est environ 12 fois celle de la dexaméthasone, 7 fois celle de l'acétonide de triamcinolone, 5 fois supérieure à celle du budésonide, et 1,5 fois celle de fluticasone. La signification clinique de ces observations est inconnue.

    Mometasone furoate Absorption

    Vaporisateur nasal est pratiquement indétectable dans le plasma

    Mometasone furoate Toxicite

    Le potentiel d'effets toxiques aigus suite d'un surdosage avec l'inhalateur de mométasone est faible. Cependant, la surutilisation habituelle du produit peut provoquer des symptômes de la surcharge des stéroïdes, notamment des irrégularités menstruelles, , L'acné, l'obésité, et une faiblesse musculaire. Des doses orales uniques allant jusqu'à 8000 mg ont été étudiées sur des volontaires humains, sans effets indésirables signalés.

    Mometasone furoate Information pour les patients

    PATIENT'S INSTRUCTIONS FOR USE ASMANEX® TWISTHALER® 220 mcg (mometasone furoate inhalation powder)

    FOR ORAL INHALATION ONLY

    Please read this leaflet carefully before taking ASMANEX® TWISTHALER®. This leaflet does not contain the complete information about this medication. If you have any questions about ASMANEX® TWISTHALER®, ask your healthcare provider or pharmacist.

    IMPORTANT POINTS TO REMEMBER ABOUT ASMANEX® TWISTHALER®

    • Your healthcare provider has prescribed ASMANEX® TWISTHALER®. It contains a medication called mometasone furoate, which is a synthetic corticosteroid. This medication is used as maintenance treatment that helps prevent and control asthma symptoms.

    • ASMANEX® TWISTHALER® is not a bronchodilator. You should not use ASMANEX® TWISTHALER® when you are having sudden symptoms of shortness of breath. Use an inhaled short-acting bronchodilator such as albuterol to relieve sudden symptoms of shortness of breath.

    • Your healthcare provider may prescribe bronchodilators such as albuterol for emergency relief if an acute asthma attack occurs.

    • The inhaler delivers your medication as a very fine powder that you may (b)(4) mell or feel. Whether or not you are able to sense of a dose, not take extra ess your healthcare provider has told you to.

    • Use the inhaler regularly and at the same time each day as prescribed by your healthcare provider. Maximum benefit may not be achieved for 1 to 2 weeks or longer. If your symptoms do not improve in that time frame or if your condition worsens, contact your healthcare provider.

    Do not use the inhaler if you notice that it is not working correctly. Take it to your healthcare provider or pharmacist.

    HOW TO USE

    Remove the ASMANEX® TWISTHALER® from its foil pouch and write the date on the cap label. It's important to throw away the inhaler 45 days after this date or when the dose counter reads "00", whichever comes first.

    Step 1. Open inhaler

    Hold the inhaler straight up with the pink portion (the base) on the bottom. It is important that you remove the cap of the TWISTHALER® while it is in this upright position to make sure that you get the right amount of medicine with each dose.

    Holding the pink base, twist the cap in a counter- clockwise direction to remove it. As you lift off the cap, the dose counter on the base will count down by one. (If you began with the dose counter reading "30," this action will cause it to now read "29.") This action loads the device with the medicine that you are now ready to inhale.

    IT IS IMPORTANT TO NOTE that the indented arrow (located on the white portion of the TWISTHALER®, directly above the pink base) is pointing to the dose counter.

    Step 2. Inhale dose

    Exhale fully. Then bring the TWISTHALER® up to your mouth with the mouthpiece facing toward you. Place it in your mouth, holding it in a horizontal position. Firmly closing your lips around the mouthpiece, take in a fast, deep breath. Since the medication is a very fine powder, you may not be able to feel or taste it after inhalation.

    Remove the TWISTHALER® from your mouth and hold your breath for about 10 seconds, or as long as you comfortably can.

    IMPORTANT: DO NOT BREATHE OUT THROUGH THE INHALER.

    After you take your medicine, it is important that you wipe the mouthpiece dry, if necessary, and immediately replace the cap, firmly closing the TWISTHALER®.

    This is the only way to be sure that your next dose is properly loaded. Be sure that the arrow is in line with the dose-counter window. The cap needs to be put back on and turned in a clockwise direction, as you gently press down. You'll hear a distinctive "click" to let you know that the cap is fully closed.

    IT IS IMPORTANT TO REPEAT STEPS 1 AND 2 EACH TIME YOU INHALE.

    Rinse your mouth after using.

    STORING YOUR INHALER

    Keep your inhaler clean and dry at all times. If the device needs cleaning, gently wipe the mouthpiece with a dry cloth or tissue as needed. Do not wash the inhaler. Avoid contact with any liquids.

    Store in a dry place at 25°C (77F°); excursions permitted to 15-30°C (59-86°F)

    Keep your inhaler out of the reach of young children.

    HOW TO KNOW WHEN YOUR INHALER IS EMPTY

    The inhaler has a dose indicator window on the pink base. It is a dose counter which displays the number of doses remaining. When the unit reads 01, this indicates the last remaining dose. After dose 01, the counter will read 00, and the cap will lock. The unit must then be discarded.

    Mometasone furoate Organismes affectes

    Les humains et autres mammifères