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ICOS 351 Les marques, ICOS 351 Analogs

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  • ICOS 351 Formule chimique

    C22H19N3O4

    ICOS 351 RX lien

    http://www.rxlist.com/cgi/generic3/cialis.htm

    ICOS 351 FDA fiche

    ICOS_351 FDA

    ICOS 351 msds (fiche de securite des materiaux)

    ICOS_351 MSDS

    ICOS 351 Synthese de reference

    Aucune information disponible

    ICOS 351 Poids moleculaire

    389.404 g/mol

    ICOS 351 Point de fusion

    301-302 oC

    ICOS 351 H2O Solubilite

    Pratiquement insoluble dans l'eau

    ICOS 351 Etat

    Solid

    ICOS 351 LogP

    1.35

    ICOS 351 Formes pharmaceutiques

    Tablet

    ICOS 351 Indication

    Utilisé pour le traitement de la dysfonction érectile

    ICOS 351 Pharmacologie

    Le tadalafil est utilisé pour traiter la dysfonction érectile (impuissance) et l'hypertension artérielle pulmonaire (HTAP). Une partie du processus physiologique de l'érection à la libération d'oxyde nitrique (NO) dans le corps caverneux. Cela active l'enzyme guanylate cyclase ce qui entraîne une augmentation des niveaux de guanosine monophosphate cyclique (GMPc), conduisant à la relaxation musculaire lisse dans les corps caverneux, entraînant l'afflux de sang et une érection. Le tadalafil est un inhibiteur puissant et sélectif de la GMPc phosphodiestérase de type 5 (PDE5) qui est responsable de la dégradation de GMPc dans les corps caverneux. Cela signifie que, avec le tadalafil sur la planche, la stimulation sexuelle normale conduit à des niveaux accrus de GMPc dans les corps caverneux qui conduit à de meilleures érections. Sans stimulation sexuelle et aucune activation du système NO / cGMP, le tadalafil ne devrait pas causer une érection.

    ICOS 351 Absorption

    Après une seule dose par voie orale d'administration, la concentration plasmatique maximale observée (C max) du tadalafil est atteint entre 30 minutes et 6 heures (temps médian de 2 heures). La biodisponibilité absolue du tadalafil après administration orale n'a pas été déterminée.

    ICOS 351 Toxicite

    Oral, rat DL50 = 2000 mg / kg, aucune mortalité ou toxicité.

    ICOS 351 Information pour les patients

    CIALIS® (See-AL-iss)

    (tadalafil) tablets

    Read the Patient Information about CIALIS before you start taking it and again each time you get a refill. There may be new information. You may also find it helpful to share this information with your partner. This leaflet does not take the place of talking with your doctor. You and your doctor should talk about CIALIS when you start taking it and at regular checkups. If you do not understand the information, or have questions, talk with your doctor or pharmacist.

    What important information should you know about CIALIS?

    CIALIS can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines. You could get dizzy, faint, or have a heart attack or stroke.

    Do not take CIALIS if you:

    • take any medicines called "nitrates."

    • use recreational drugs called "poppers" like amyl nitrate and butyl nitrate.

    • take medicines called alpha blockers, other than Flomax (tamsulosin HCl) 0.4 mg daily.

     

    Tell all your healthcare providers that you take CIALIS. If you need emergency medical care for a heart problem, it will be important for your healthcare provider to know when you last took CIALIS.

    After taking a single tablet, some of the active ingredient of CIALIS remains in your body for more than 2 days. The active ingredient can remain longer if you have problems with your kidneys or liver, or you are taking certain other medications.

    What is CIALIS?

    CIALIS is a prescription medicine taken by mouth for the treatment of erectile dysfunction (ED) in men.

    ED is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. A man who has trouble getting or keeping an erection should see his doctor for help if the condition bothers him. CIALIS may help a man with ED get and keep an erection when he is sexually excited.

    CIALIS does not:

    • cure ED

    • increase a man's sexual desire

    • protect a man or his partner from sexually transmitted diseases, including HIV. Speak to your doctor about ways to guard against sexually transmitted diseases.

    • serve as a male form of birth control

    CIALIS is only for men with ED. CIALIS is not for women or children. CIALIS must be used only under a doctor's care.

    How does CIALIS work?

    When a man is sexually stimulated, his body's normal physical response is to increase blood flow to his penis. This results in an erection. CIALIS helps increase blood flow to the penis and may help men with ED get and keep an erection satisfactory for sexual activity. Once a man has completed sexual activity, blood flow to his penis decreases, and his erection goes away.

    Who can take CIALIS?

    Talk to your doctor to decide if CIALIS is right for you.

    CIALIS has been shown to be effective in men over the age of 18 years who have erectile dysfunction, including men with diabetes or who have undergone prostatectomy.

    Who should not take CIALIS? Do not take CIALIS if you:

    take any medicines called "nitrates" . Nitrates are commonly used to treat angina. Angina is a symptom of heart disease and can cause pain in your chest, jaw, or down your arm. Medicines called nitrates include nitroglycerin that is found in tablets, sprays, ointments, pastes, or patches. Nitrates can also be found in other medicines such as isosorbide dinitrate or isosorbide mononitrate. Some recreational drugs called "poppers" also contain nitrates, such as amyl nitrate and butyl nitrate. Do not use CIALIS if you are using these drugs. Ask your doctor or pharmacist if you are not sure if any of your medicines are nitrates.

    take medicines called "alpha blockers", other than Flomax® 0.4 mg daily. Alpha blockers are sometimes prescribed for prostate problems or high blood pressure. If CIALIS is taken with alpha blockers other than Flomax 0.4 mg daily, your blood pressure could suddenly drop to an unsafe level. You could get dizzy and faint.

    you have been told by your healthcare provider to not have sexual activity because of health problems. Sexual activity can put an extra strain on your heart, especially if your heart is already weak from a heart attack or heart disease.

    are allergic to CIALIS or any of its ingredients. The active ingredient in CIALIS is called tadalafil. See the end of this leaflet for a complete list of ingredients.

    What should you discuss with your doctor before taking CIALIS?

    Before taking CIALIS, tell your doctor about all your medical problems, including if you:

    have heart problems such as angina, heart failure, irregular heartbeats, or have had a heart attack. Ask your doctor if it is safe for you to have sexual activity.

    have low blood pressure or have high blood pressure that is not controlled

    have had a stroke

    have liver problems

    have kidney problems or require dialysis

    have retinitis pigmentosa, a rare genetic (runs in families) eye disease

    have stomach ulcers

    have a bleeding problem

    have a deformed penis shape or Peyronie's disease

    have had an erection that lasted more than 4 hours

    have blood cell problems such as sickle cell anemia, multiple myeloma, or leukemia

    Can other medications affect CIALIS?

    Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. CIALIS and other medicines may affect each other. Always check with your doctor before starting or stopping any medicines. Especially tell your doctor if you take any of the following:

    • medicines called nitrates

    • medicines called alpha blockers. These include Hytrin® (terazosin), Flomax® (tamsulosin), Cardura® (doxazosin), Minipress® (prazosin) or Uroxatral® (alfuzosin).

    • ritonavir (Norvir®) or indinavir (Crixivan®)

    • ketoconazole or itraconazole (such as Nizoral® or Sporanox®)

    • erythromycin

    • other medicines or treatments for ED

    How should you take CIALIS?

    Take CIALIS exactly as your doctor prescribes. CIALIS comes in different doses (5 mg, 10 mg, and 20 mg). For most men, the recommended starting dose is 10 mg. CIALIS should be taken no more than once a day. Some men can only take a low dose of CIALIS because of medical conditions or medicines they take. Your doctor will prescribe the dose that is right for you.

    • If you have kidney problems, your doctor may start you on a lower dose of CIALIS.

    • If you have kidney or liver problems or you are taking certain medications, your doctor may limit your highest dose of CIALIS to 10 mg and may also limit you to one tablet in 48 hours (2 days) or one tablet in 72 hours (3 days). Take one CIALIS tablet before sexual activity. In some patients, the ability to have sexual activity was improved at 30 minutes after taking CIALIS when compared to a sugar pill. The ability to have sexual activity was improved up to 36 hours after taking CIALIS when compared to a sugar pill. You and your doctor should consider this in deciding when you should take CIALIS prior to sexual activity. Some form of sexual stimulation is needed for an erection to happen with CIALIS. CIALIS may be taken with or without meals.

    Do not change your dose of CIALIS without talking to your doctor. Your doctor may lower your dose or raise your dose, depending on how your body reacts to CIALIS.

    Do not drink alcohol to excess when taking CIALIS (for example, 5 glasses of wine or 5 shots of whiskey). When taken in excess, alcohol can increase your chances of getting a headache or getting dizzy, increasing your heart rate, or lowering your blood pressure.

    If you take too much CIALIS, call your doctor or emergency room right away.

    What are the possible side effects of CIALIS?

    The most common side effects with CIALIS are headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually go away after a few hours. Patients who get back pain and muscle aches usually get it 12 to 24 hours after taking CIALIS. Back pain and muscle aches usually go away by themselves within 48 hours. Call your doctor if you get a side effect that bothers you or one that will not go away.

    CIALIS may uncommonly cause:

    an erection that won't go away (priapism) - If you get an erection that lasts more than 4 hours, get medical help right away. Priapism must be treated as soon as possible or lasting damage can happen to your penis including the inability to have erections.

    vision changes - such as seeing a blue tinge to objects or having difficulty telling the difference between the colors blue and green. These are not all the side effects of CIALIS. For more information, ask your doctor or pharmacist.

    How should CIALIS be stored?

    • Store CIALIS at room temperature between 59 and 86 F (15 and 30 C).

    Keep CIALIS and all medicines out of the reach of children.

    General Information about CIALIS:

    Medicines are sometimes prescribed for conditions other than those described in patient information leaflets. Do not use CIALIS for a condition for which it was not prescribed. Do not give CIALIS to other people, even if they have the same symptoms that you have. It may harm them.

    This leaflet summarizes the most important information about CIALIS. If you would like more information, talk with your healthcare provider. You can ask your doctor or pharmacist for information about CIALIS that is written for health professionals.

    For more information you can also visit www.cialis.com, or call 1-877-242-5441.

    What are the ingredients of CIALIS?

    Active Ingredient: tadalafil

    Inactive Ingredients: croscarmellose sodium, hydroxypropyl cellulose, hypromellose, iron oxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, talc, titanium dioxide, and triacetin.

    Norvir® (ritonavir) and Hytrin® (terazosin) are registered trademarks of Abbott Laboratories Crixivan® (indinavir sulfate) is a registered trademark of Merck & Co., Inc. Nizoral® (ketoconazole) and Sporanox® (itraconazole) are registered trademarks of Janssen Pharmaceutica, Inc. Flomax® (tamsulosin) is a registered trademark of Boehringer Ingelheim Pharmaceuticals, Inc. Cardura® (doxazosin) and Minipress® (prazosin) are registered trademarks of Pfizer, Inc. Uroxatral® (alfuzosin) is a registered trademark of Sanofi-Synthelabo

     

    ICOS 351 Organismes affectes

    Les humains et autres mammifères