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Alplax Les marques, Alplax Analogs

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  • Alplax Formule chimique

    C17H13ClN4

    Alplax RX lien

    http://www.rxlist.com/cgi/generic/alpraz.htm

    Alplax FDA fiche

    Alplax FDA

    Alplax msds (fiche de securite des materiaux)

    Alplax MSDS

    Alplax Synthese de reference

    JB Hester, le brevet américain. 3.987.052 (1976).

    Alplax Poids moleculaire

    308.765 g/mol

    Alplax Point de fusion

    228-228.5oC

    Alplax H2O Solubilite

    40 mg / L à pH 7, 12 mg / ml à pH 1,2

    Alplax Etat

    Solid

    Alplax LogP

    4.251

    Alplax Formes pharmaceutiques

    Comprimés (0,25 mg, 0,5, 1 ou 2)

    Alplax Indication

    Pour la gestion de l'anxiété ou le soulagement à court terme des symptômes d'anxiété et pour le traitement du trouble panique, avec ou sans agoraphobie.

    Alplax Pharmacologie

    Alprazolam, une benzodiazépine, est utilisé pour traiter le trouble panique et le trouble d'anxiété. Contrairement chlordiazépoxide, le clorazépate, et prazépam, l'alprazolam a une courte demi-vie et de ses métabolites avec une activité minimale. Comme les benzodiazépines triazolo d'autres telles que le triazolam, l'alprazolam peut avoir d'importantes interactions médicamenteuses impliquant le cytochrome P-450 3A4 isoenzyme. Cliniquement, toutes les benzodiazépines causent une relation dose- liées l'activité nerveuse centrale dépresseur du système variant de déficience légère de l'exécution des tâches à l'hypnose. Contrairement à d'autres benzodiazépines, l'alprazolam peut aussi avoir une certaine activité antidépressive, mais preuves cliniques de ce manque.

    Alplax Absorption

    Facilement absorbé par le tractus gastro-intestinal. La biodisponibilité est de 80-90%.

    Alplax Toxicite

    Oral, souris: DL50 = 1020 mg / kg. Les symptômes de surdose comprennent la confusion, le coma, l'incoordination, la somnolence et le temps de réaction ralenti.

    Alplax Information pour les patients

    Alprazolam is used for the treatment of anxiety, panic disorder, and insomnia. Inform your physican if you are pregnant or nursing. Alprazolam may cause dizziness and drowsiness; use caution while driving or operating hazardous machinery. Do not take any other sedating drugs or drink alcohol while taking this medication. Alprazolam may be habit forming. Withdrawal symptoms may occur after you stop taking it. Alprazolam may be taken with or without food.

    For All Users of Alprazolam

    To assure safe and effective use of benzodiazepines, all patients prescribed alprazolam should be provided with the following guidance. In addition, panic disorder patients, for whom doses greater than 4 mg/day are typically prescribed, should be advised about the risks associated with the use of higher doses.

    1. Inform your physician about any alcohol consumption and medicine you are taking now, including medication you may buy without a prescription. Alcohol should generally not be used during treatment with benzodiazepines.

    2. Not recommended for use in pregnancy. Therefore, inform your physician if you are pregnant, if you are planning to have a child, or if you become pregnant while you are taking this medication.

    3. Inform your physician if you are nursing.

    4. Until you experience how this medication affects you, do not drive a car or operate potentially dangerous machinery, etc.

    5. Do not increase the dose even if you think the medication "does not work anymore" without consulting your physician. Benzodiazepines, even when used as recommended, may produce emotional and/or physical dependence.

    6. Do not stop taking this medication abruptly or decrease the dose without consulting your physician, since withdrawal symptoms can occur.

    Additional Advice for Panic Disorder Patients

    The use of alprazolam at doses greater than 4 mg/day, often necessary to treat panic disorder, is accompanied by risks that you need to carefully consider. When used at high doses greater than 4 mg/day, which may or may not be required for your treatment, alprazolam has the potential to cause severe emotional and physical dependence in some patients and these patients may find it exceedingly difficult to terminate treatment. In two controlled trials of 6 to 8 weeks duration where the ability of patients to discontinue medication was measured, 7-29% of patients treated with alprazolam did not completely taper off therapy. In a controlled postmarketing discontinuation study of panic disorder patients, the patients treated with doses of alprazolam greater than 4 mg/day had more difficulty tapering to zero dose than patients treated with less than 4 mg/day. In all cases, it is important that your physician help you discontinue this medication in a careful and safe manner to avoid overly extended use of alprazolam.

    In addition, the extended use at doses greater than 4 mg/day appears to increase the incidence and severity of withdrawal reactions when alprazolam is discontinued. These are generally minor but seizure can occur, especially if you reduce the dose too rapidly or discontinue the medication abruptly. Seizure can be life-threatening.

    Alplax Organismes affectes

    Les humains et autres mammifères