Categoria
Diphenoxylate
Nombres de marca,
Diphenoxylate
Analogos
Diphenoxylate
Marca los nombres de mezcla
Lomotil (Atropine Sulfate + Diphenoxylate Hcl)
Diphenoxylate
Formula quimica
C30H32N2O2
Diphenoxylate
RX enlace
http://www.rxlist.com/cgi/generic3/diphenoxylate.htm
Diphenoxylate
FDA hoja
Diphenoxylate
MSDS (hoja de seguridad de materiales)
Diphenoxylate
Sintesis de referencia
Janssen, EE.UU. Pat. 2,898,340 (1959)
Diphenoxylate
Peso molecular
452.587 g/mol
Diphenoxylate
Punto de fusion
221 oC
Diphenoxylate
H2O Solubilidad
0,8 mg / ml
Diphenoxylate
Estado
Solid
Diphenoxylate
LogP
7.385
Diphenoxylate
Formas de dosificacion
Solución oral; Tablet
Diphenoxylate
Indicacion
Para la terapia como adyuvante en el tratamiento de la diarrea
Diphenoxylate
Farmacologia
Difenoxilato, un antidiarreico, es eficaz como tratamiento adyuvante en el tratamiento de la diarrea. Difenoxilato es rápida y extensamente metabolizado en el hombre por hidrólisis del éster del ácido diphenoxylic (difenoxine), que es biológicamente activo y el principal metabolito en la sangre.
Diphenoxylate
Absorcion
90%
Diphenoxylate
Toxicidad
Coma, piel seca y las membranas mucosas, dilatación de las pupilas de los ojos, la temperatura corporal extremadamente alta, enrojecimiento facial, movimiento involuntario del globo ocular, menor que el tono muscular normal, pupilas, taquicardia, agitación, lentitud, suprime la respiración
Diphenoxylate
Informacion de Pacientes
INFORM THE PATIENT (PARENT OR GUARDIAN) NOT TO EXCEED THE RECOMMENDED DOSAGE AND TO KEEP DIPHEN-OXYLATE HCL AND
ATROPINE SULFATE OUT OF THE REACH OF CHILDREN AND IN A CHILD-RESISTANT CONTAINER, INFORM THE PATIENT OF THE
CONSEQUENCES OF OVERDOSAGE, INCLUDING SEVERE RESPIRATORY DEPRESSION AND COMA, POSSIBLY LEADING TO PERMANENT BRAIN
DAMAGE OR DEATH.
Diphenoxylate HCl and atropine sulfate may produce drowsiness or dizziness. The patient should be cautioned
regarding activities requiring mental alertness, such as driving or operati ng dangerous machinery. Potentiation of
the action of alcohol, barbiturates and tranquilizers with concomitant use of diphenoxylate HCl and atropine sulfate
should be explained to the patient. The physician should also provide the patient with other information in this
labeling, as appropriate.
Diphenoxylate
Organismos afectados
Humanos y otros mamíferos