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Brand names,
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Analogs
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Brand Names Mixture
- Bellergal Spacetabs (Belladonna + Ergotamine Tartrate + Phenobarbital)
- Bellergal Tab (Belladonna + Ergotamine (Ergotamine Tartrate) + Phenobarbital)
- Cafergot Pb Sup (Belladonna + Caffeine + Ergotamine (Ergotamine Tartrate) + Pentobarbital)
- Cafergot Pb Tab (Belladonna + Caffeine + Ergotamine (Ergotamine Tartrate) + Pentobarbital Sodium)
- Cafergot Sup (Caffeine + Ergotamine Tartrate)
- Cafergot Tab (Caffeine + Ergotamine Tartrate)
- Ergodryl Cap (Caffeine Citrate + Diphenhydramine Hydrochloride + Ergotamine Tartrate)
- Gravergol Capsules (Caffeine + Dimenhydrinate + Ergotamine Tartrate)
- Megral Tabs (Caffeine + Cyclizine Hydrochloride + Ergotamine Tartrate)
- Wigraine Suppositories (Belladonna + Caffeine + Ergotamine Tartrate)
- Wigraine Tab (Belladonna + Caffeine + Ergotamine Tartrate)
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Chemical_Formula
C33H35N5O5
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RX_link
http://www.rxlist.com/cgi/generic2/ergotamine.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
581.662 g/mol
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Melting Point
213.5 oC
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H2O Solubility
Slight
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State
Solid
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LogP
2.53
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Dosage Forms
Tablet
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Indication
For use as therapy to abort or prevent vascular headache, e.g., migraine, migraine variants, or so called "histaminic cephalalgia".
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Pharmacology
Ergotamine is a vasoconstrictor and alpha adrenoreceptor antagonist. The pharmacological properties of ergotamine are extremely complex; some of its actions are unrelated to each other, and even mutually antagonistic. The drug has partial agonist and/or antagonist activity against tryptaminergic, dopaminergic and alpha adrenergic receptors depending upon their site, and it is a highly active uterine stimulant. It causes constriction of peripheral and cranial blood vessels and produces depression of central vasomotor centers. The pain of a migraine attack is believed to be due to greatly increased amplitude of pulsations in the cranial arteries, especially the meningeal branches of the external carotid artery. Ergotamine reduces extracranial blood flow, causes a decline in the amplitude of pulsation in the cranial arteries, and decreases hyperperfusion of the territory of the basilar artery. It does not reduce cerebral hemispheric blood flow.
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Absorption
No information avaliable
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side effects and Toxicity
Signs of overexposure include irritation, nausea, vomiting, headache, diarrhea, thirst, coldness of skin, pruritus, weak pulse, numbness, tingling of extremities, and confusion.
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals