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Brand names,
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Analogs
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Brand Names Mixture
- Cosopt -(2%/0.5% Oph Dps) (Dorzolamide (Dorzolamide Hydrochloride) + Timolol (Timolol Maleate))
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Chemical_Formula
C10H16N2O4S3
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RX_link
http://www.rxlist.com/cgi/generic/dorzolamide.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
J. J. Baldwin et al., Eur. pat. Appl. 296,879; eidem, U.S. pat. 4,797,413 (1988, 1989 both to Merck & Co.)
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Molecular Weight
324.443 g/mol
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Melting Point
283-285 oC
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H2O Solubility
No information avaliable
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State
Solid
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LogP
0.548
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Dosage Forms
Solution
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Indication
For the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma
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Pharmacology
Dorzolamide is topical carbonic anhydrase inhibitor. Dorzolamide is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers.
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Absorption
No information avaliable
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side effects and Toxicity
Dizziness, headache, shortness of breath, slow heartbeat, severe asthma, cardiac arrest
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Patient Information
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Organisms Affected
Humans and other mammals