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Trovafloxacin Brand names, Trovafloxacin Analogs

Trovafloxacin Brand Names Mixture

  • No information avaliable

Trovafloxacin Chemical_Formula


Trovafloxacin RX_link

Trovafloxacin fda sheet

Trovafloxacin msds (material safety sheet)

Trovafloxacin Synthesis Reference

No information avaliable

Trovafloxacin Molecular Weight

416.353 g/mol

Trovafloxacin Melting Point

No information avaliable

Trovafloxacin H2O Solubility

12.3 mg/L

Trovafloxacin State


Trovafloxacin LogP


Trovafloxacin Dosage Forms

Liquid for infusion; Tablets

Trovafloxacin Indication

For treatment of infections caused by susceptible strains of the designated microorganisms in uncomplicated urethral gonorrhea in males and endocervical and rectal gonorrhea in females caused by Neisseria gonorrhoeae as well as non gonoccocal urethritis and cervicitis due to Chlamydia trachomatis.

Trovafloxacin Pharmacology

Trovafloxacin is a broad spectrum antibiotic that inhibits DNA supercoiling in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It is not used widely due to the risk of hepatotoxicity. It tends to have better gram-positive bacterial coverage and less gram-negative coverage than the previous fluoroquinolones. Mechanism of action of fluoroquinolones including trovafloxacin is different from that of penicillins, cephalosporins, aminoglycosides, macrolides, and tetracyclines. Therefore fluoroquinolones may be active against pathogens that are resistant to these antibiotics. There is no cross-resistance between trovafloxacin and the mentioned classes of antibiotics. The overall results obtained from in vitro synergy studies, testing combinations of trovafloxacin with beta-lactams and aminoglycosides, indicate that synergy is strain specific and not commonly encountered. This agrees with results obtained previously with other fluoroquinolones. Resistance to trovafloxacin in vitro develops slowly via multiple-step mutation in a manner similar to other fluoroquinolones. Resistance to trovafloxacin in vitro occurs at a general frequency of between 1x10-7 to 10-10. Although cross-resistance has been observed between trovafloxacin and some other fluoroquinolones, some microorganisms resistant to other fluoroquinolones may be susceptible to trovafloxacin.

Trovafloxacin Absorption

Well-absorbed from the gastrointestinal tract after oral administration and does not depend on concomitant food intake. The absolute bioavailability is approximately 88%.

Trovafloxacin side effects and Toxicity

Symptoms of overdose include convulsions, decreased activity, diarrhea, sleepiness, tremors, and/or vomiting.

Trovafloxacin Patient Information

No information avaliable

Trovafloxacin Organisms Affected

Enteric bacteria and other eubacteria