Tranexamic acid EP/JP/CP

Antiemetics

Tranexamic acid EP/JP/CP Brand names, Tranexamic acid EP/JP/CP Analogs

Tranexamic acid EP/JP/CP Brand Names Mixture

No information avaliable

Tranexamic acid EP/JP/CP Chemical_Formula

C₂₁H₂₈N₂O₅

Tranexamic acid EP/JP/CP RX_link

http://www.rxlist.com/cgi/generic3/trimethbenz.htm

Tranexamic acid EP/JP/CP fda sheet

Tranexamic_acid_EP/JP/CP FDA

Tranexamic acid EP/JP/CP msds (material safety sheet)

Tranexamic_acid_EP/JP/CP MSDS

Tranexamic acid EP/JP/CP Synthesis Reference

No information avaliable

Tranexamic acid EP/JP/CP Molecular Weight

388.458 g/mol

Tranexamic acid EP/JP/CP Melting Point

188.7 ^oC

Tranexamic acid EP/JP/CP H₂O Solubility

40 mg/L

Tranexamic acid EP/JP/CP State

Solid

Tranexamic acid EP/JP/CP LogP

2.784

Tranexamic acid EP/JP/CP Dosage Forms

Capsules (300 mg) for oral administration; Suppositories (200 mg); Injectable (100 mg, 200 mg)

Tranexamic acid EP/JP/CP Indication

For the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.

Tranexamic acid EP/JP/CP Pharmacology

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.

Tranexamic acid EP/JP/CP Absorption

The relative bioavailability of the capsule formulation compared to the solution is 100%.

Tranexamic acid EP/JP/CP side effects and Toxicity

Oral LD₅₀ in mice is 1600 mg/kg.

Tranexamic acid EP/JP/CP Patient Information