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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C20H24N2O
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
308.417 g/mol
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Melting Point
94-95 oC
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H2O Solubility
1.88 mg/L
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State
Solid
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LogP
4.535
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Dosage Forms
Extended release tablets (50, 75, 100 mg)
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Indication
For the treatment of life-threatening dysrhythmias and sustained ventricular tachycardia.
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Pharmacology
Indecainide is a rarely used antidysrhythmic. Indecainide has local anesthetic activity and belongs to the membrane stabilizing (Class 1) group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the IC class of antiarrhythmics.
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Absorption
Nearly complete following oral administration.
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side effects and Toxicity
When given orally to either young adult rats or mice, the LD50 was 100 mg/kg. Symptoms of overdose include nausea and vomiting, convulsions, hypotension, bradycardia, syncope, extreme widening of the QRS complex, widening of the QT interval, widening of the PR interval, ventricular tachycardia, AV nodal block, asystole, bundle branch block, cardiac failure, and cardiac arrest.
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Patient Information
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Organisms Affected
Humans and other mammals