TMX

• Antibiotics
• Antimetabolites, Antineoplastic
• Antifungal Agents
• Folic Acid Antagonists
• Antiprotozoals
• ATC:P01AX07

• Neutrexin
• TMQ
• TMX
• Trimetrexate (USAN)
• Trimetrexate [USAN:BAN:INN]
• Trimetrexato [INN-Spanish]
• Trimetrexatum [INN-Latin]

• No information avaliable

C₁₉H₂₃N₅O₃

http://www.rxlist.com/cgi/generic2/trimetrexate.htm

TMX FDA

No information avaliable

369.418 g/mol

215-217 ^oC

31.4 mg/L

Solid

2.2

Powder for solution (containing trimetrexate glucuronate equivalent to either 200 mg or 25 mg of trimetrexate)

For use, with concurrent leucovorin administration (leucovorin protection), as an alternative therapy for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients, including patients with the acquired immunodeficiency syndrome (AIDS). Also used to treat several types of cancer including colon cancer.

Trimetrexate, a non-classical folate antagonist, is a synthetic inhibitor of the enzyme dihydrofolate reductase (DHFR). During DNA synthesis and cellular reproduction, folic acid is reduced to tetrahydrofolic acid by the enzyme folic acid reductase. By interfering with the reduction of folic acid, trimetrexate interferes with tissue cell reproduction. Generally, the most sensitive cells to the antimetabolite effect of trimetrexate are those cells which are most actively proliferating such as malignant cells, dermal epithelium, buccal and intestinal mucosa, bone marrow, fetal cells, and cells of the urinary bladder. Because the proliferation of cells in malignant tissues is greater than in most normal tissues, trimetrexate may impair the growth of the malignant tissues without causing irreversible damage to normal tissues. Due to very serious and potentially life-threatening side-effects of this drug, leucovorin must be co-administered for at least 72 hours after the last dose.

No information avaliable

The LD₅₀ of intravenous trimetrexate in mice is 62 mg/kg (186 mg/m²). Myelosuppression is a dose-limiting toxic effect.

While you are being treated with trimetrexate, and after you stop treatment, do not have any immunizations (vaccinations) without your doctor’s okay. Try to avoid contact with people who have recently taken the oral polio vaccine. Check with your doctor about this. Trimetrexate can lower your blood counts (white blood cells, red blood cells, platelets). Your doctor will check your blood counts before and after each treatment to see its effect. Your doctor or nurse will give you specific instructions if your blood counts are low. Trimetrexate can decrease your white blood cell count. This can increase your risk of getting an infection. Report fever of 100.5°F or higher, or signs of infection such as pain in passing your urine, coughing, and bringing up sputum. Trimetrexate can decrease your platelet count. This can increase your risk of bleeding. DO NOT take any aspirin or aspirin–containing medicines. Report unusual bruising, or bleeding such as nosebleeds, bleeding gums when you brush your teeth, or black, tarry stools. Getting a wig before starting treatment may make it easier to deal with hair loss. Talk to your nurse or doctor about this. If your insurance does not cover it, there may be other resources to help you. Hair loss is temporary, and your hair will grow back after treatment.

Humans, other mammals, bacteria and protozoa