Riluzole HCl en es it fr

Riluzole HCl Brand names, Riluzole HCl Analogs

Riluzole HCl Brand Names Mixture

  • No information avaliable

Riluzole HCl Chemical_Formula


Riluzole HCl RX_link

Riluzole HCl fda sheet

Riluzole HCl msds (material safety sheet)

Riluzole HCl Synthesis Reference

No information avaliable

Riluzole HCl Molecular Weight

234.199 g/mol

Riluzole HCl Melting Point

119 oC

Riluzole HCl H2O Solubility

No information avaliable

Riluzole HCl State


Riluzole HCl LogP


Riluzole HCl Dosage Forms


Riluzole HCl Indication

For the treatment of amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease)

Riluzole HCl Pharmacology

Riluzole, a member of the benzothiazole class, is indicated for the treatment of patients with amyotrophic lateral sclerosis (ALS). Riluzole extends survival and/or time to tracheostomy. It is also neuroprotective in various in vivo experimental models of neuronal injury involving excitotoxic mechanisms. The etiology and pathogenesis of amyotrophic lateral sclerosis (ALS) are not known, although a number of hypotheses have been advanced. One hypothesis is that motor neurons, made vulnerable through either genetic predisposition or environmental factors, are injured by glutamate. In some cases of familial ALS the enzyme superoxide dismutase has been found to be defective.

Riluzole HCl Absorption

Riluzole is well-absorbed (approximately 90%), with average absolute oral bioavailability of about 60% (CV=30%). A high fat meal decreases absorption, reducing AUC by about 20% and peak blood levels by about 45%.

Riluzole HCl side effects and Toxicity

No information avaliable

Riluzole HCl Patient Information

Patients should be advised to report any febrile illness to their physicians .

Patients and caregivers should be advised that RILUTEK should be taken on a regular basis and at the same time of the day (e.g., in the morning and evening) each day. If a dose is missed, take the next tablet as originally planned.

Patients should be warned about the potential for dizziness, vertigo, or somnolence and advised not to drive or operate machinery until they have gained sufficient experience on RILUTEK to gauge whether or not it affects their mental and/or motor performance adversely.

Whether alcohol increases the risk of serious hepatotoxicity with RILUTEK is unknown; therefore, patients being treated with RILUTEK should be discouraged from drinking excessive amounts of alcohol.

Patients should also be made aware that RILUTEK should be stored at temperatures between 20°-25°C (68°-77°F) and protected from bright light.

RILUTEK must be kept out of the reach of children.

Riluzole HCl Organisms Affected

Humans and other mammals