Rifabutin

Rifabutin Brand names, Rifabutin Analogs

Rifabutin Brand Names Mixture

No information avaliable

Rifabutin Chemical_Formula

C₄₆H₆₂N₄O₁₁

Rifabutin RX_link

http://www.rxlist.com/cgi/generic2/rifabutin.htm

Rifabutin fda sheet

Rifabutin FDA

Rifabutin msds (material safety sheet)

Rifabutin MSDS

Rifabutin Synthesis Reference

No information avaliable

Rifabutin Molecular Weight

847.005 g/mol

Rifabutin Melting Point

No information avaliable

Rifabutin H₂O Solubility

Minimally soluble (0.19 mg/mL)

Rifabutin State

Solid

Rifabutin LogP

4.218

Rifabutin Dosage Forms

Capsule

Rifabutin Indication

For the prevention of disseminated Mycobacterium avium complex (MAC) disease in patients with advanced HIV infection.

Rifabutin Pharmacology

Rifabutin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifabutin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency.

Rifabutin Absorption

Rifabutin is readily absorbed from the gastrointestinal tract, with an absolute bioavailability averaging 20%.

Rifabutin side effects and Toxicity

LD₅₀ = 4.8 g/kg (mouse, male)

Rifabutin Patient Information

Patients should be advised of the signs and symptoms of both MAC and tuberculosis, and should be instructed to consult their physicians if they develop new complaints consistent with either of these diseases. In addition, since MYCOBUTIN may rarely be associated with myositis and uveitis, patients should be advised to notify their physicians if they develop signs or symptoms suggesting either of these disorders.

Urine, feces, saliva, sputum, perspiration, tears, and skin may be colored brown-orange with rifabutin and some of its metabolites. Soft contact lenses may be permanently stained. Patients to be treated with MYCOBUTIN should be made aware of these possibilities.

Rifabutin Organisms Affected

Enteric bacteria and other eubacteria