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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C19H27N5
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
325.451 g/mol
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Melting Point
No information avaliable
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H2O Solubility
Soluble
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State
Solid
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LogP
No information avaliable
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Dosage Forms
Ophthalmic solution (eye drops, 0.5%); Ophthalmic powder for reconstitution (0.5%)
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Indication
Used in the treatment of iatrogenically induced mydriasis produced by adrenergic (phenylephrine) or parasympatholytic (tropicamide) agents used in certain eye examinations.
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Pharmacology
Dapiprazole is an alpha-adrenergic blocking agent. It produces miosis by blocking the alpha-adrenergic receptors on the dilator muscle of the iris. Dapiprazole produces no significant action on ciliary muscle contraction and thus, there are no changes in the depth of the anterior chamber of the thickness of the lens. It does not alter the IOP either in normal eyes or in eyes with elevated IOP. The rate of pupillary constriction may be slightly slower in clients with brown irises than in clients with blue or green irises.
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Absorption
Systemic absorption is negligible.
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side effects and Toxicity
Oral LD50 is 1189—2100 mg/kg in mice, rats and rabbits.
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Patient Information
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Organisms Affected
Humans and other mammals