ReoPro
Brand names,
ReoPro
Analogs
ReoPro
Brand Names Mixture
ReoPro
Chemical_Formula
C6462H9964N1690O2049S48
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RX_link
http://www.rxlist.com/cgi/generic2/abcixim.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
(sequence listed in Kohmura C, Gold HK, Yasuda T, Holt R, Nedelman MA, Guerrero JL, Weisman HF, Collen D. A chimeric murine/human antibody Fab fragment directed against the platelet GPIIb/IIIa receptor enhances and sustains arterial thrombolysis with recombinant tissue-type plasminogen activator in baboons.Arterioscler Thromb. 1993 Dec;13(12):1837-42.) patent EP418316
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Molecular Weight
145651.1
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Melting Point
61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000).
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H2O Solubility
No information avaliable
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State
Liquid
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LogP
-0.424
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Dosage Forms
Solution (IV Infusion)
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Indication
For treatment of myocardial infarction, adjunct to percutaneous coronory intervention, unstable angina
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Pharmacology
Used for the treatment of myocardial infarction and the prevention of platelet aggregation. Abciximab inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules to GPIIb/IIIa receptor sites on activated platelets.
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Absorption
No information avaliable
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side effects and Toxicity
No information avaliable
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals