Primachin
Primachin Brand names, Primachin Analogs
Primachin Brand Names Mixture
- No information avaliable
Primachin Chemical_Formula
C15H21N3O
Primachin RX_link
No information avaliable
Primachin fda sheet
Primachin msds (material safety sheet)
Primachin Synthesis Reference
No information avaliable
Primachin Molecular Weight
259.347 g/mol
Primachin Melting Point
< 25 oC
Primachin H2O Solubility
No information avaliable
Primachin State
Solid
Primachin LogP
2.145
Primachin Dosage Forms
Tablet
Primachin Indication
For the treatment of malaria.
Primachin Pharmacology
Primaquine is an antimalarial agent and is the essential co-drug with chloroquine in treating all cases of malaria. In the blood, malaria parasites break down a part of the red blood cells known as haemoglobin. When this happens haemoglobin is divided into two parts; haem and globin. Haem is toxic to the malaria parasite. To prevent it from being damaged, the malaria parasite produces an chemical which converts the toxic haem into a non-toxic product. Primaquine acts by interfering with a part of the parasite (mitochondria) that is responsible for supplying it with energy. Without energy the parasite dies. This stops the infection from continuing and allows the person to recover. Primaquine kills the intrahepatic form of Plasmodium vivax and Plasmodium ovale, and thereby prevents the development of the erythrocytic forms that are responsible for relapses (it also kills gametocytes). Primaquine is not used in the prevention of malaria, only in the treatment. It has insignificant activity against the asexual blood forms of the parasite and therefore it is always used in conjunction with a blood schizonticide and never as a single agent. Primaquine has gametocytocidal activity against all plasmodia, including P. falciparum.
Primachin Absorption
No information avaliable
Primachin side effects and Toxicity
No information avaliable
Primachin Patient Information
No information avaliable
Primachin Organisms Affected
Plasmodium
