Phytonadione (JP14/USP)
Phytonadione (JP14/USP) Brand names, Phytonadione (JP14/USP) Analogs
- α-Phylloquinone
- 1,4-Naphthoquinone, 2-methyl-3-phytyl-
- 2', 3'-trans-Vitamin K1
- 2-Methyl-3-phythyl-1,4-naphthochinon
- 3-Phytylmenadione
- Antihemorrhagic vitamin
- Aqua-Mephytin
- AquaMEPHYTON
- Combinal K1
- K-Ject
- Kativ N
- Kephton
- Kinadion
- Konakion
- M.V.I. Pediatric
- Menadione
- Mephyton
- Mephyton (TN)
- Mono-Kay
- Monodion
- Phyllochinon
- Phylloquinone
- Phythyl-menadion
- Phythyl-menadion (GERMAN)
- Phytomenadione
- Phytonadione (JP14/USP)
- Phytylmenadione
- Synthex P
- VITAMIN K1
- Vitamin K
- Vitamin K1 (VAN)
- Vitaped
Phytonadione (JP14/USP) Brand Names Mixture
- No information avaliable
Phytonadione (JP14/USP) Chemical_Formula
C31H46O2
Phytonadione (JP14/USP) RX_link
http://www.rxlist.com/cgi/generic3/phytonadione.htm
Phytonadione (JP14/USP) fda sheet
Phytonadione (JP14/USP) msds (material safety sheet)
Phytonadione (JP14/USP) Synthesis Reference
No information avaliable
Phytonadione (JP14/USP) Molecular Weight
450.696 g/mol
Phytonadione (JP14/USP) Melting Point
-20 oC
Phytonadione (JP14/USP) H2O Solubility
Insoluble in water
Phytonadione (JP14/USP) State
Liquid
Phytonadione (JP14/USP) LogP
8.841
Phytonadione (JP14/USP) Dosage Forms
Liquid
Phytonadione (JP14/USP) Indication
For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia
Phytonadione (JP14/USP) Pharmacology
Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).
Phytonadione (JP14/USP) Absorption
Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
Phytonadione (JP14/USP) side effects and Toxicity
No information avaliable
Phytonadione (JP14/USP) Patient Information
No information avaliable
Phytonadione (JP14/USP) Organisms Affected
Humans and other mammals
