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Nicotinic acid (JP14) Brand names, Nicotinic acid (JP14) Analogs

Nicotinic acid (JP14) Brand Names Mixture

  • No information avaliable

Nicotinic acid (JP14) Chemical_Formula


Nicotinic acid (JP14) RX_link

No information avaliable

Nicotinic acid (JP14) fda sheet

Nicotinic acid (JP14) msds (material safety sheet)

Nicotinic acid (JP14) Synthesis Reference

No information avaliable

Nicotinic acid (JP14) Molecular Weight

123.111 g/mol

Nicotinic acid (JP14) Melting Point

237 oC

Nicotinic acid (JP14) H2O Solubility

Slightly soluble in water.

Nicotinic acid (JP14) State


Nicotinic acid (JP14) LogP


Nicotinic acid (JP14) Dosage Forms

No information avaliable

Nicotinic acid (JP14) Indication

For nutritional supplementation, also for treating dietary shortage or imbalance.

Nicotinic acid (JP14) Pharmacology

Niacin, also known as nicotinic acid or vitamin B3, is a water-soluble vitamin whose derivatives such as NADH play essential roles in energy metabolism in the living cell. The designation vitamin B3 also includes the amide form, nicotinamide or niacinamide. Severe lack of niacin causes the deficiency disease pellagra, whereas a mild deficiency slows down the metabolism, which in turn decreases cold tolerance and is a potential contributing factor towards obesity. The body can synthesize niacin from the essential amino acid tryptophan, but the synthesis is extremely slow. Large doses of niacin are sometimes prescribed to combat high blood pressure, and also to lower blood cholesterol levels. Pharmacologic doses of niacin (1.5 to 6 grams/day) reduce LDL cholesterol levels by 10 to 25 percent and triglyceride levels by 20 to 50 percent. HDL cholesterol levels are also increased by 15 to 35 percent.1 Brand-name medications include Niaspan®, Niacor® and Nicolor®. Treatment doses cause flushing in individuals not previously exposed to large doses of niacin, so titration to increasing doses is necessary upon starting the medication. Vitamin B3 has also been used to treat schizophrenia and other mental illnesses by orthomolecular practitioners. Usually the nicotinamide form is used, as it is considered to be more effective. Unfortunately there is little scientific evidence that this treatment is effective. Because niacin promotes metabolism, some believe that taking large doses will speed up the elimination of THC from the body and produce a negative result for marijuana on a drug test. There is no evidence that this is effective, and niacin is toxic to the skin and liver in overdose.

Nicotinic acid (JP14) Absorption

No information avaliable

Nicotinic acid (JP14) side effects and Toxicity

Oral rat LD50: 7,000 mg/kg. Investigated as a tumorigen.

Nicotinic acid (JP14) Patient Information

No information avaliable

Nicotinic acid (JP14) Organisms Affected

Humans and other mammals