Naproxen
Naproxen Brand names, Naproxen Analogs
Naproxen Brand Names Mixture
- No information avaliable
Naproxen Chemical_Formula
C14H14O3
Naproxen RX_link
http://www.rxlist.com/cgi/generic/naproxsod.htm
Naproxen fda sheet
Naproxen msds (material safety sheet)
Naproxen Synthesis Reference
No information avaliable
Naproxen Molecular Weight
230.259 g/mol
Naproxen Melting Point
153 oC
Naproxen H2O Solubility
15.9 mg/L
Naproxen State
Solid
Naproxen LogP
3.313
Naproxen Dosage Forms
Suppository; Suspension; Tablet; Tablet (enteric-coated); Tablet (extended-release)
Naproxen Indication
For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis, and acute gout. Also for the relief of mild to moderate pain and the treatment of primary dysmenorrhea.
Naproxen Pharmacology
Naproxen is a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Naproxen has analgesic and antipyretic properties. As with other NSAIDs, its mode of action is not fully understood; however, its ability to inhibit prostaglandin synthesis may be involved in the anti-inflammatory effect.
Naproxen Absorption
Naproxen itself is rapidly and completely absorbed from the GI tract with an in vivo bioavailability of 95%. Although naproxen itself is well absorbed, the sodium salt form is more rapidly absorbed resulting in higher peak plasma levels for a given dose. Food causes a slight decrease in the rate absorption.
Naproxen side effects and Toxicity
ORAL (LD50): Acute: 248 mg/kg [Rat]. 360 mg/kg [Mouse]. Symptoms of overdose include drowsiness, heartburn, indigestion, nausea, and vomiting.
Naproxen Patient Information
Naproxen Organisms Affected
Humans and other mammals
