Memantine Hydrochloride
Memantine Hydrochloride Brand names, Memantine Hydrochloride Analogs
Memantine Hydrochloride Brand Names Mixture
- No information avaliable
Memantine Hydrochloride Chemical_Formula
C12H21N
Memantine Hydrochloride RX_link
http://www.rxlist.com/cgi/generic3/namenda.htm
Memantine Hydrochloride fda sheet
Memantine Hydrochloride msds (material safety sheet)
Memantine Hydrochloride Synthesis Reference
No information avaliable
Memantine Hydrochloride Molecular Weight
179.302 g/mol
Memantine Hydrochloride Melting Point
258 oC (HCl salt)
Memantine Hydrochloride H2O Solubility
35 mg/mL (HCl salt), 0.9 mg/mL for free base
Memantine Hydrochloride State
Solid
Memantine Hydrochloride LogP
2.197
Memantine Hydrochloride Dosage Forms
Tablet
Memantine Hydrochloride Indication
For the treatment of moderate to severe dementia of the Alzheimer's type.
Memantine Hydrochloride Pharmacology
Memantine, an amantadine derivative, is an NMDA receptor antagonist used in the treatment of Alzheimer's disease. It differs from traditional agents used in Alzheimer's disease by acting on glutamatergic neurotransmission, rather than cholinergic. There is some evidence that dysfunction of glutamatergic neurotransmission, manifested as neuronal excitotoxicity, is involved in the aetiology of Alzheimer's disease (Cacabelos et al., 1999). As such, targeting the glutamatergic system, specifically NMDA receptors, was a novel approach to treatment in view of the limited efficacy of existing drugs targeting the cholinergic system. A systematic review of randomised controlled trials found that memantine has a positive effect on cognition, mood, behaviour, and the ability to perform daily activities. There is no evidence that memantine prevents or slows neurodegeneration in patients with Alzheimer's disease.
Memantine Hydrochloride Absorption
Well absorbed orally with a bioavailability of approximately 100%. Peak plasma concentrations are reached in 3-7 hours. Food has no effect on absorption.
Memantine Hydrochloride side effects and Toxicity
Side effects include pain, abnormal crying, leg pain, fever, increased apetite. Adverse drug reactions include: dizziness, confusion, headache, hallucinations, tiredness. Less common side effects include: vomiting, anxiety, hypertonia, cystitis, and increased libido. Doses of up to 400 mg have been tolerated.
Memantine Hydrochloride Patient Information
Information for Patients and Caregivers: Caregivers should be instructed in the recommended administration (twice per day for doses above 5 mg) and dose escalation (minimum interval of one week between dose increases).
Memantine Hydrochloride Organisms Affected
Humans and other mammals
