Laronidase
Brand names,
Laronidase
Analogs
Laronidase
Brand Names Mixture
Laronidase
Chemical_Formula
C3160H4848N898O881S12
Laronidase
RX_link
http://www.rxlist.com/cgi/generic3/aldurazyme.htm
Laronidase
fda sheet
Laronidase
msds (material safety sheet)
Laronidase
Synthesis Reference
No information avaliable
Laronidase
Molecular Weight
69899.4
Laronidase
Melting Point
Mandelli J, Wajner A, Pires R, Giugliani R, Coelho JC. Detection of mucopolysaccharidosis type I heterozygotes on the basis of the biochemical properties of plasma alpha-L-iduronidase. Clin Chim Acta. 2001 Oct;312(1-2):81-6.
Laronidase
H2O Solubility
No information avaliable
Laronidase
State
Liquid
Laronidase
LogP
-0.300
Laronidase
Dosage Forms
Solution (IV infusion)
Laronidase
Indication
For the treatment of mucopolysaccharidosis
Laronidase
Pharmacology
Laronidase is used to treat mucopolysaccharide storage disorders (specifically mucopolysaccharidosis 1 or Hurlers syndrome) caused by deficiencies of alpha-L-iduronidase. Reduced or absent a-L-iduronidase activity results in the accumulation of the GAG substrates, dermatan sulfate and heparan sulfate, throughout the body and leads to widespread cellular, tissue, and organ dysfunction.
Laronidase
Absorption
No information avaliable
Laronidase
side effects and Toxicity
No information avaliable
Laronidase
Patient Information
No information avaliable
Laronidase
Organisms Affected
Humans and other mammals