L-(-)-Tryptophan
Brand names,
L-(-)-Tryptophan
Analogs
L-(-)-Tryptophan
Brand Names Mixture
L-(-)-Tryptophan
Chemical_Formula
C11H12N2O2
L-(-)-Tryptophan
RX_link
No information avaliable
L-(-)-Tryptophan
fda sheet
L-(-)-Tryptophan
msds (material safety sheet)
L-(-)-Tryptophan
Synthesis Reference
No information avaliable
L-(-)-Tryptophan
Molecular Weight
204.228 g/mol
L-(-)-Tryptophan
Melting Point
280-285 oC
L-(-)-Tryptophan
H2O Solubility
Soluble
L-(-)-Tryptophan
State
Solid
L-(-)-Tryptophan
LogP
-1.429
L-(-)-Tryptophan
Dosage Forms
Capsules, Tablets
L-(-)-Tryptophan
Indication
Tryptophan may be useful in increasing serotonin production, promoting healthy sleep, managing depression by enhancing mental and emotional well-being, managing pain tolerance, and managing weight.
L-(-)-Tryptophan
Pharmacology
Tryptophan is critical for the production of the body's proteins, enzymes and muscle tissue. It is also essential for the production of niacin, the synthesis of the neurotransmitter serotonin and melatonin. Tryptophan supplements can be used as natural relaxants to help relieve insomnia. Tryptophan can also reduce anxiety and depression and has been shown to reduce the intensity of migraine headaches. Other promising indications include the relief of chronic pain, reduction of impulsivity or mania and the treatment of obsessive or compulsive disorders. Tryptophan also appears to help the immune system and can reduce the risk of cardiac spasms. Tryptophan deficiencies may lead to coronary artery spasms. Tryptophan is used as an essential nutrient in infant formulas and intravenous feeding. Tryptophan is marketed as a prescription drug (Tryptan) for those who do not seem to respond well to conventional antidepressants. It may also be used to treat those afflicted with seasonal affective disorder (a winter-onset depression). Tryptopan serves as the precursor for the synthesis of serotonin (5-hydroxytryptamine, 5-HT) and melatonin (N-acetyl-5-methoxytryptamine).
L-(-)-Tryptophan
Absorption
No information avaliable
L-(-)-Tryptophan
side effects and Toxicity
Oral rat LD50: > 16 gm/kg. Investigated as a tumorigen, mutagen, reproductive effector. Symptoms of overdose include agitation, confusion, diarrhea, fever, overactive reflexes, poor coordination, restlessness, shivering, sweating, talking or acting with excitement you cannot control, trembling or shaking, twitching, and vomiting.
L-(-)-Tryptophan
Patient Information
It is important that your doctor check your progress at regular visits, to allow dosage adjustments and help reduce any side effects.
L-(-)-Tryptophan
Organisms Affected
Humans and other mammals