Kemadrine
Kemadrine Brand names, Kemadrine Analogs
Kemadrine Brand Names Mixture
- No information avaliable
Kemadrine Chemical_Formula
C19H29NO
Kemadrine RX_link
No information avaliable
Kemadrine fda sheet
Kemadrine msds (material safety sheet)
Kemadrine Synthesis Reference
Adamson, U.S. pat. 2,891,890 (1959 to Burroughs Wellcome)
Kemadrine Molecular Weight
287.44 g/mol
Kemadrine Melting Point
86 oC
Kemadrine H2O Solubility
Moderately soluble in water, ~ 30 mg/ml
Kemadrine State
Solid
Kemadrine LogP
4.37
Kemadrine Dosage Forms
Tablet; Elixir
Kemadrine Indication
For the treatment of Parkinson's Disease (especially drug induced)
Kemadrine Pharmacology
Procyclidine has an atropine-like action. It's antispasmodic effects are thought to be related to the blockage of central cholinergic receptors M1, M2 and M4. It is used to treat symptomatic Parkinsonism and extrapyramidal dysfunction caused by antipsychotic agents.
Kemadrine Absorption
No information avaliable
Kemadrine side effects and Toxicity
LD50=60 mg/kg (IV in mice)
Kemadrine Patient Information
Patient Information:
Follow your doctors instructions for taking this medicine. This medicine can be taken with food or a snack,
to minimize stomach upset. As your body becomes used to the medicine, it should be taken on an empty
stomach. Talk to your doctor about the best time of day to take the medicine. For patients taking the
extended-release forms, swallow the tablet whole, do NOT CRUSH or CHEW. You may break the tablet in half
if the whole pill is too large for you to take.
This medicine can cause dizziness or drowsiness. Be cautious when driving or performing other hazardous
activities. This medicine can impair judgment. Do NOT increase your dose of this medicine without first
talking to your doctor, even if you feel that the medicine is not working.
Discuss the risks and benefits of using this medicine during pregnancy. It is unknown whether this medicine
is excreted in breast milk. DO NOT breastfeed while taking this medicine until you have talked to your
doctor or pediatrician.
Follow your doctors instructions for taking this medicine. This medicine can be taken with food or a snack,
to minimize stomach upset. As your body becomes used to the medicine, it should be taken on an empty
stomach. Talk to your doctor about the best time of day to take the medicine. For patients taking the
extended-release forms, swallow the tablet whole, do NOT CRUSH or CHEW. You may break the tablet in half
if the whole pill is too large for you to take.
This medicine can cause dizziness or drowsiness. Be cautious when driving or performing other hazardous
activities. This medicine can impair judgment. Do NOT increase your dose of this medicine without first
talking to your doctor, even if you feel that the medicine is not working.
Discuss the risks and benefits of using this medicine during pregnancy. It is unknown whether this medicine
is excreted in breast milk. DO NOT breastfeed while taking this medicine until you have talked to your
doctor or pediatrician.
Kemadrine Organisms Affected
Humans and other mammals
