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Indinavir sulfate Brand names, Indinavir sulfate Analogs

Indinavir sulfate Brand Names Mixture

  • No information avaliable

Indinavir sulfate Chemical_Formula

C36H47N5O4

Indinavir sulfate RX_link

http://www.rxlist.com/cgi/generic2/indinav.htm

Indinavir sulfate fda sheet

Indinavir_sulfate FDA

Indinavir sulfate msds (material safety sheet)

Indinavir_sulfate MSDS

Indinavir sulfate Synthesis Reference

J. P. Vacca et al U.S.pat. 5,413,999 (1995)

Indinavir sulfate Molecular Weight

613.79 g/mol

Indinavir sulfate Melting Point

167.5-168 oC

Indinavir sulfate H2O Solubility

0.015 mg/ml

Indinavir sulfate State

Solid

Indinavir sulfate LogP

2.569

Indinavir sulfate Dosage Forms

Oral capsules

Indinavir sulfate Indication

For the treatment of HIV infection.

Indinavir sulfate Pharmacology

Indinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Indinavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.

Indinavir sulfate Absorption

Rapidly absorbed

Indinavir sulfate side effects and Toxicity

Symptoms of overdose include myocardial infarction and angina pectoris.

Indinavir sulfate Patient Information

A statement to patients and health care providers is included on the product’s bottle label. ALERT: Find out about medicines that should NOT be taken with CRIXIVAN. A Patient Package Insert (PPI) for CRIXIVAN is available for patient information.

CRIXIVAN is not a cure for HIV infection and patients may continue to develop opportunistic infections and other complications associated with HIV disease. The long-term effects of CRIXIVAN are unknown at this time. CRIXIVAN has not been shown to reduce the risk of transmission of HIV to others through sexual contact or blood contamination.

Patients should be advised to remain under the care of a physician when using CRIXIVAN and should not modify or discontinue treatment without first consulting the physician. Therefore, if a dose is missed, patients should take the next dose at the regularly scheduled time and should not double this dose. Therapy with CRIXIVAN should be initiated and maintained at the recommended dosage.

CRIXIVAN may interact with some drugs; therefore, patients should be advised to report to their doctor the use of any other prescription, non-prescription medication or herbal products, particularly St. John’s wort.

For optimal absorption, CRIXIVAN should be administered without food but with water 1 hour before or 2 hours after a meal. Alternatively, CRIXIVAN may be administered with other liquids such as skim milk, juice, coffee, or tea, or with a light meal, e.g., dry toast with jelly, juice, and coffee with skim milk and sugar; or corn flakes, skim milk and sugar. Ingestion of CRIXIVAN with a meal high in calories, fat, and protein reduces the absorption of indinavir.

Patients receiving a phosphodiesterase type 5 (PDE5) inhibitor (sildenafil, tadalafil, or vardenafil) should be advised that they may be at an increased risk of PDE5 inhibitor-associated adverse events including hypotension, visual changes, and priapism, and should promptly report any symptoms to their doctors.

Patients should be informed that redistribution or accumulation of body fat may occur in patients receiving antiretroviral therapy and that the cause and long-term health effects of these conditions are not known at this time.

CRIXIVAN Capsules are sensitive to moisture. Patients should be informed that CRIXIVAN should be stored and used in the original container and the desiccant should remain in the bottle.

Indinavir sulfate Organisms Affected

Human immunodeficiency virus