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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C15H14FN3O3
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RX_link
http://www.rxlist.com/cgi/generic3/flumazenil.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
303.288 g/mol
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Melting Point
201-203 oC
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H2O Solubility
128 mg/L
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State
Solid
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LogP
1.468
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Dosage Forms
Solution for injection (0.1 mg/mL)
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Indication
For the complete or partial reversal of the sedative effects of benzodiazepines in cases where general anesthesia has been induced and/or maintained with benzodiazepines, where sedation has been produced with benzodiazepines for diagnostic and therapeutic procedures, and for the management of benzodiazepine overdose.
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Pharmacology
Flumazenil does not antagonize the central nervous system effects of drugs affecting GABA-ergic neurons by means other than the benzodiazepine receptor (including ethanol, barbiturates, or general anesthetics) and does not reverse the effects of opioids.
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Absorption
No information avaliable
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side effects and Toxicity
In clinical studies, most adverse reactions to flumazenil were an extension of the pharmacologic effects of the drug in reversing benzodiazepine effects.
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Patient Information
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Organisms Affected
Humans and other mammals