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Hydroxyurea Brand names, Hydroxyurea Analogs

Hydroxyurea Brand Names Mixture

  • No information avaliable

Hydroxyurea Chemical_Formula

CH4N2O2

Hydroxyurea RX_link

http://www.rxlist.com/cgi/generic2/hydroxyurea.htm

Hydroxyurea fda sheet

Hydroxyurea FDA

Hydroxyurea msds (material safety sheet)

Hydroxyurea MSDS

Hydroxyurea Synthesis Reference

No information avaliable

Hydroxyurea Molecular Weight

76.0547 g/mol

Hydroxyurea Melting Point

142-146 oC

Hydroxyurea H2O Solubility

1E+006 mg/L

Hydroxyurea State

Solid

Hydroxyurea LogP

-1.432

Hydroxyurea Dosage Forms

Capsule

Hydroxyurea Indication

For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.

Hydroxyurea Pharmacology

Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.

Hydroxyurea Absorption

Well absorbed from the gastrointestinal tract.

Hydroxyurea side effects and Toxicity

Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg

Hydroxyurea Patient Information

HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.

Hydroxyurea Organisms Affected

Humans and other mammals