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Gabapentine Brand names, Gabapentine Analogs

Gabapentine Brand Names Mixture

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Gabapentine Chemical_Formula


Gabapentine RX_link

Gabapentine fda sheet

Gabapentine FDA

Gabapentine msds (material safety sheet)

Gabapentine MSDS

Gabapentine Synthesis Reference

G Satzinger et al., U.S. Pat. 4,024,175 (1977).

Gabapentine Molecular Weight

171.237 g/mol

Gabapentine Melting Point

162-166 oC

Gabapentine H2O Solubility

4490 mg/L

Gabapentine State


Gabapentine LogP


Gabapentine Dosage Forms

Capsule; Tablet (oral); Solution (oral)

Gabapentine Indication

For the management of postherpetic neuralgia in adults and as adjunctive therapy in the treatment of partial seizures with and without secondary generalization in patients over 12 years of age with epilepsy.

Gabapentine Pharmacology

Gabapentin, an analog of GABA, is used as an anticonvulsant to treat partial seizures, amyotrophic lateral sclerosis (ALS), and painful neuropathies. Potential uses include monotherapy of refractory partial seizure disorders, and treatment of spasticity in multiple sclerosis, tremor. mood disorders, and attenuation of disruptive behaviors in dementia. Gabapentin has high lipid solubility, is not metabolized by the liver, has no protein binding, and doesn't possess the usual drug interactions.

Gabapentine Absorption

Rapid. Absorbed in part by the L-amino acid transport system, which is a carrier-mediated, saturable transport system; as the dose increases, bioavailability decreases. Bioavailability ranges from approximately 60% for a 900 mg dose per day to approximately 27% for a 4800 milligram dose per day. Food has a slight effect on the rate and extent of absorption of gabapentin (14% increase in AUC).

Gabapentine side effects and Toxicity

Symptoms of overdose include ataxia, labored breathing, ptosis, sedation, hypoactivity, and excitation.

Gabapentine Patient Information

Patients should be instructed to take Neurontin only as prescribed.

Patients should be advised that Neurontin may cause dizziness, somnolence and other symptoms and signs of CNS depression. Accordingly, they should be advised neither to drive a car nor to operate other complex machinery until they have gained sufficient experience on Neurontin to gauge whether or not it affects their mental and/or motor performance adversely. Patients who require concomitant treatment with morphine may experience increases in gabapentin concentrations. Patients should be carefully observed for signs of CNS depression, such as somnolence, and the dose of Neurontin or morphine should be reduced appropriately.

Gabapentine Organisms Affected

Humans and other mammals