Estazolam
Brand names,
Estazolam
Analogs
Estazolam
Brand Names Mixture
Estazolam
Chemical_Formula
C16H11ClN4
Estazolam
RX_link
http://www.rxlist.com/cgi/generic2/estaz.htm
Estazolam
fda sheet
Estazolam
msds (material safety sheet)
Estazolam
Synthesis Reference
No information avaliable
Estazolam
Molecular Weight
294.738 g/mol
Estazolam
Melting Point
228.5 oC
Estazolam
H2O Solubility
Practically insoluble (1.5 mg/L)
Estazolam
State
Solid
Estazolam
LogP
4.08
Estazolam
Dosage Forms
Tablet (1 mg or 2 mg); Solution
Estazolam
Indication
For the short-term management of insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings, and/or early morning awakenings.
Estazolam
Pharmacology
Estazolam, a triazolobenzodiazepine derivative, is an oral hypnotic agent with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam.
Estazolam
Absorption
Tablets have been found to be equivalent in absorption to an orally administered solution of estazolam. In healthy subjects who received up to three times the recommended dose, peak estazolam plasma concentrations occurred within two hours after dosing (range 0.5 to 6.0 hours) and were proportional to the administered dose, suggesting linear pharmacokinetics over the dosage range tested.
Estazolam
side effects and Toxicity
Symptoms of overdose include confusion, depressed breathing, drowsiness and eventually coma, lack of coordination, and slurred speech.
Estazolam
Patient Information
No information avaliable
Estazolam
Organisms Affected
Humans and other mammals