Escitalopram Oxalate
Brand names,
Escitalopram Oxalate
Analogs
Escitalopram Oxalate
Brand Names Mixture
Escitalopram Oxalate
Chemical_Formula
C20H21FN2O
Escitalopram Oxalate
RX_link
http://www.rxlist.com/cgi/generic/lexapro.htm
Escitalopram Oxalate
fda sheet
Escitalopram Oxalate
msds (material safety sheet)
Escitalopram Oxalate
Synthesis Reference
No information avaliable
Escitalopram Oxalate
Molecular Weight
324.392 g/mol
Escitalopram Oxalate
Melting Point
No information avaliable
Escitalopram Oxalate
H2O Solubility
No information avaliable
Escitalopram Oxalate
State
Solid
Escitalopram Oxalate
LogP
4.222
Escitalopram Oxalate
Dosage Forms
Tablet
Escitalopram Oxalate
Indication
For the treatment of major depressive disorder and Generalized Anxiety Disorder (GAD).
Escitalopram Oxalate
Pharmacology
Escitalopram is one of a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of escitalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. In vitro studies show that escitalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram was found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase.
Escitalopram Oxalate
Absorption
The absolute bioavailability of citalopram is about 80% relative to an intravenous dose
Escitalopram Oxalate
side effects and Toxicity
Signs of overdose include convulsions, coma, dizziness, hypotension, insomnia, nausea, vomiting, sinus tachycardia, somnolence, and ECG changes (including QT prolongation).
Escitalopram Oxalate
Patient Information
Escitalopram Oxalate
Organisms Affected
Humans and other mammals