Erythromycin
Erythromycin Brand names, Erythromycin Analogs
Erythromycin Brand Names Mixture
- No information avaliable
Erythromycin Chemical_Formula
C37H67NO13
Erythromycin RX_link
http://www.rxlist.com/cgi/generic/erithrom.htm
Erythromycin fda sheet
Erythromycin msds (material safety sheet)
Erythromycin Synthesis Reference
No information avaliable
Erythromycin Molecular Weight
733.927 g/mol
Erythromycin Melting Point
191 oC
Erythromycin H2O Solubility
Slightly soluble (1.44 mg/L)
Erythromycin State
Solid
Erythromycin LogP
1.983
Erythromycin Dosage Forms
Capsule; Capsule (enteric-coated); Liquid; Ointment; Powder; Powder for solution; Solution; Suspension; Tablet; Tablet (enteric-coated)
Erythromycin Indication
For use in the treatment of infections caused by susceptible strains of microorganisms in the following diseases: respiratory tract infections (upper and lower) of mild to moderate degree, pertussis (whooping cough), as adjunct to antitoxin in infections due to Corynebacterium diphtheriae, in the treatment of infections due to Corynebacterium minutissimum, intestinal amebiasis caused by Entamoeba histolytica, acute pelvic inflammatory disease caused by Neisseria gonorrhoeae, skin and soft tissue infections of mild to moderate severity caused by Streptococcus pyogenes and Staphylococcus aureus, primary syphilis caused by Treponema pallidum, infections caused by Chlamydia trachomatis, nongonococcal urethritis caused by Ureaplasma urealyticum, and Legionnaires' disease caused by Legionella pneumophila.
Erythromycin Pharmacology
Erythromycin is produced by a strain of Streptomyces erythraeus and belongs to the macrolide group of antibiotics. After absorption, erythromycin diffuses readily into most body fluids. In the absence of meningeal inflammation, low concentrations are normally achieved in the spinal fluid, but the passage of the drug across the blood-brain barrier increases in meningitis. Erythromycin is excreted in breast milk. The drug crosses the placental barrier, but fetal plasma levels are low. Erythromycin is not removed by peritoneal dialysis or hemodialysis.
Erythromycin Absorption
Orally administered erythromycin base and its salts are readily absorbed in the microbiologically active form. Topical application of the ophthalmic ointment to the eye may result in absorption into the cornea and aqueous humor.
Erythromycin side effects and Toxicity
Symptoms of overdose include diarrhea, nausea, stomach cramps, and vomiting.
Erythromycin Patient Information
Erythromycin Organisms Affected
Enteric bacteria and other eubacteria
