Enflurane

• Anesthetics, Inhalation
• General Anesthetics
• ATC:N01AB04

• Alyrane
• Anesthetic 347
• Anesthetic Compound No. 347
• Chlorotrifluoroethyldifluoromethylether2
• Compound 347
• Efrane
• Enflurane(USAN)
• Enflurano [INN-Spanish]
• Enfluranum [INN-Latin]
• Ethrane
• Methylflurether
• Ohio 347

• No information avaliable

C₃H₂ClF₅O

No information avaliable

Enflurane MSDS

No information avaliable

184.492 g/mol

56 ^oC (boiling point)

Practically insoluble (5620 mg/L)

Liquid

2.597

Liquid

Used for the induction and maintenance of general anaesthesia during surgery and cesarean section and also used for analgesia during vaginal delivery.

Enflurane is an extremely stable halogenated ether inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate. Enflurane induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. Induction of and recovery from anesthesia with enflurane are rapid. Enflurane may provide a mild stimulus to salivation or tracheobronchial secretions. Pharyngeal and laryngeal reflexes are readily obtunded. In the cardiovascular system, enflurane is a mild negative inotrope, causing a marked decrease in systemic vascular resistance, thus leading to a decrease in mean arterial pressure. This results in a reflex tachycardia. Enflurane also decreases coronary vascular resistance and sensitizes the myocardium to circulating catecholamines. Enflurane is a strong respiratory depressant. It decreases tidal volume but may increase respiratory rate. It also causes bronchodilatationa and inhibits pulmonary macrophage activity and mucociliary activity. Enflurane principle action in the CNS is general anaesthesia with little analgesic effect. It causes increased cerebral blood flow in concentrations and may induce tonic/clonic muscle activity and epileptiform EEG traces. It also causes a marked decrease in skeletal muscle tone. Actions in the genitourinary system include a decreased renal blood flow and glomerular filtration rate and the tone of pregnant uterus is decreased.

Rapidly absorbed into the circulation via the lungs.

LD₅₀=5.4 ml/kg (oral, rat). Symptoms of acute overdose include nausea, vomiting, irritation to the eyes, skin and nose/throat, headache, dizziness, and drowsiness. Symptoms of chronic overdose include hypotension, cardiac arrhythmias, respiratory depression, and liver/kidney dysfunction.

No information avaliable

Humans and other mammals