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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C17H21N
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RX_link
http://www.rxlist.com/cgi/generic/benzphet.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
239.355 g/mol
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Melting Point
152-153 oC
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H2O Solubility
Readily soluble
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State
Solid
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LogP
4.374
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Dosage Forms
Tablet (scored)
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Indication
For the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction
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Pharmacology
Benzphetamine, a phenylalkylamin, is related to amphetamine both chemically and pharmacologically. It is an anorectic agent indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction. Benzphetamine is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.
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Absorption
Readily absorbed from the gastro-intestinal tract and buccal mucosa. It Is resistant to metabolism by monoamine oxidase.
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side effects and Toxicity
LD50=160 mg/kg (orally in rats). Acute overdosage may result in restlessness, tremor, tachypnea, confusion, assaultiveness, and panic states.
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Patient Information
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Organisms Affected
Humans and other mammals