Cefditoren Pivaloyloxymethyl Ester

Cefditoren Pivaloyloxymethyl Ester Brand names, Cefditoren Pivaloyloxymethyl Ester Analogs

Cefditoren Pivaloyloxymethyl Ester Brand Names Mixture

No information avaliable

Cefditoren Pivaloyloxymethyl Ester Chemical_Formula

C₂₅H₂₈N₆O₇S₃

Cefditoren Pivaloyloxymethyl Ester RX_link

http://www.rxlist.com/cgi/generic3/spectracef.htm

Cefditoren Pivaloyloxymethyl Ester fda sheet

Cefditoren_Pivaloyloxymethyl_Ester FDA

Cefditoren Pivaloyloxymethyl Ester msds (material safety sheet)

Cefditoren Pivaloyloxymethyl Ester Synthesis Reference

No information avaliable

Cefditoren Pivaloyloxymethyl Ester Molecular Weight

620.724 g/mol

Cefditoren Pivaloyloxymethyl Ester Melting Point

127 - 129 ^oC

Cefditoren Pivaloyloxymethyl Ester H₂O Solubility

Soluble at levels equal to < 0.1 mg/mL.

Cefditoren Pivaloyloxymethyl Ester State

Solid

Cefditoren Pivaloyloxymethyl Ester LogP

2.721

Cefditoren Pivaloyloxymethyl Ester Dosage Forms

Tablets (200mg) for oral administration.

Cefditoren Pivaloyloxymethyl Ester Indication

For the treatment of mild to moderate infections in adults and adolescents (12 years of age or older) which are caused by susceptible strains of microorganisms in acute bacterial exacerbation of chronic bronchitis, community-acquired pneumonia, pharyngitis/tonsillitis, and uncomplicated skin and skin-structure infections.

Cefditoren Pivaloyloxymethyl Ester Pharmacology

Cefditoren pivoxil is a prodrug which is hydrolyzed by esterases during absorption, and the drug is distributed in the circulating blood as active cefditoren. Cefditoren is a cephalosporin with antibacterial activity against gram-positive and gram-negative pathogens. Cefditoren is effective against Staphylococcus aureus (methicillin-susceptible strains, including b-lactamase-producing strains), penicillin-susceptible strains of Staphylococcus aureus and Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae (including b-lactamase-producing strains), Haemophilus parainfluenzae (including b-lactamase-producing strains), Moraxella catarrhalis (including b-lactamase-producing strains), Streptococcus agalactiae, Streptococcus Groups C and G, and Streptococcus, viridans group (penicillin-susceptible and -intermediate strains).

Cefditoren Pivaloyloxymethyl Ester Absorption

Following oral administration, cefditoren pivoxil is absorbed from the gastrointestinal tract and hydrolyzed to cefditoren by esterases. Under fasting conditions, the estimated absolute bioavailability of cefditoren pivoxil is approximately 14%. The absolute bioavailability of cefditoren pivoxil administered with a low fat meal (693 cal, 14 g fat, 122 g carb, 23 g protein) is 16.1 ± 3.0%.

Cefditoren Pivaloyloxymethyl Ester side effects and Toxicity

Information on cefditoren pivoxil overdosage in humans is not available. However, with other b-lactam antibiotics, adverse effects following overdosage have included nausea, vomiting, epigastric distress, diarrhea, and convulsions. In acute animal toxicity studies, cefditoren pivoxil when tested at the limit oral doses of 5100 mg/kg in rats and up to 2000 mg/kg in dogs did not exhibit any health effects of concern.

Cefditoren Pivaloyloxymethyl Ester Patient Information