Caffeine, Anhydrous
Brand names,
Caffeine, Anhydrous
Analogs
Caffeine, Anhydrous
Brand Names Mixture
Caffeine, Anhydrous
Chemical_Formula
C8H10N4O2
Caffeine, Anhydrous
RX_link
http://www.rxlist.com/cgi/generic3/caffeine.htm
Caffeine, Anhydrous
fda sheet
Caffeine, Anhydrous
msds (material safety sheet)
Caffeine, Anhydrous
Synthesis Reference
U.S. Pat. 2,508,545 (1950)
Caffeine, Anhydrous
Molecular Weight
194.191 g/mol
Caffeine, Anhydrous
Melting Point
238 oC
Caffeine, Anhydrous
H2O Solubility
22 mg/ml
Caffeine, Anhydrous
State
Solid
Caffeine, Anhydrous
LogP
-0.07
Caffeine, Anhydrous
Dosage Forms
Capsule; Drops; Liquid; Pill; Tablet
Caffeine, Anhydrous
Indication
For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.
Caffeine, Anhydrous
Pharmacology
Caffeine, a naturally occurring xanthine derivative like theobromine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates with apnea of prematurity). Often combined with analgesics or with ergot alkaloids, caffeine is used to treat migraine and other headache types. Over the counter, caffeine is available to treat drowsiness or mild water-weight gain.
Caffeine, Anhydrous
Absorption
Readily absorbed after oral or parenteral administration. The peak plasma level for caffeine range from 6-10mg/L and the mean time to reach peak concentration ranged from 30 minutes to 2 hours.
Caffeine, Anhydrous
side effects and Toxicity
LD50=127 mg/kg (orally in mice)
Caffeine, Anhydrous
Patient Information
Caffeine, Anhydrous
Organisms Affected
Humans and other mammals