PharmacyCodes



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CFDN Brand names, CFDN Analogs

CFDN Brand Names Mixture

  • No information avaliable

CFDN Chemical_Formula

C14H13N5O5S2

CFDN RX_link

http://www.rxlist.com/cgi/generic2/cefdin.htm

CFDN fda sheet

CFDN FDA

CFDN msds (material safety sheet)

CFDN MSDS

CFDN Synthesis Reference

No information avaliable

CFDN Molecular Weight

395.416 g/mol

CFDN Melting Point

No information avaliable

CFDN H2O Solubility

No information avaliable

CFDN State

Solid

CFDN LogP

0.657

CFDN Dosage Forms

Capsules for oral administration (300mg); Oral suspension (125mg per 5mL solution)

CFDN Indication

For the treatment of the respiratory, skin, soft tissue, and ENT infections caused by H. influenzae (including b-lactamase producing strains), H. parainfluenzae (including b-lactamase producing strains), S. pneumoniae (penicillin-susceptible strains), S. pyogenes, S. aureus (including b-lactamase producing strains), and M. catarrhalis.

CFDN Pharmacology

Cefdinir is a third generation cephalosporin with a broad spectrum of activity against enteric gram-negative rods. Cefdinir is stable in the presence of some, but not all, b-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins are susceptible to cefdinir. Cephalosporins work the same way as penicillins: they interfere with the peptidoglycan synthesis of the bacterial wall by inhibiting the final transpeptidation needed for the cross-links. This effect is bactericidal.

CFDN Absorption

Maximal plasma cefdinir concentrations occur 2 to 4 hours postdose following capsule or suspension administration. Estimated bioavailability of cefdinir capsules is 21% following administration of a 300 mg capsule dose, and 16% following administration of a 600 mg capsule dose. Estimated absolute bioavailability of cefdinir suspension is 25%. Absorption is reduced by approximately 15% when administered with a high fat meal.

CFDN side effects and Toxicity

Information on cefdinir overdosage in humans is not available. In acute rodent toxicity studies, a single oral 5600-mg/kg dose produced no adverse effects. Toxic signs and symptoms following overdosage with other b-lactam antibiotics have included nausea, vomiting, epigastric distress, diarrhea, and convulsions.

CFDN Patient Information

CFDN Organisms Affected

Enteric gram-negative rods